Altered Effective Connectivity of the Primary Motor Cortex in Stroke: A Resting-State fMRI Study with Granger Causality Analysis.
Altered Effective Connectivity of the Primary Motor Cortex in Stroke: A Resting-State fMRI Study with Granger Causality Analysis.
复制标题
中风时初级运动皮层有效连通性的改变：基于格兰杰因果分析的静息态功能磁共振成像研究
DOI：
10.1371/journal.pone.0166210
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Gong J
中科院分区：
文献类型：
--
作者：
Zhao Z;Wang X;Fan M;Yin D;Sun L;Jia J;Tang C;Zheng X;Jiang Y;Wu J;Gong J
在伴有运动障碍的中风患者中，初级运动皮层（M1）经常异常募集。然而，鲜为人知的是，在中风后的因果连接的M1的改变。本研究的目的是调查是否同病灶的M1的有效连接被扰乱中风患者显示不同的结果，手运动功能。选择23例左半球皮质下卒中患者，分为部分瘫痪手（PPH）和完全瘫痪手（CPH）两个亚组。此外，招募了24名匹配的健康对照（HC）。采用体素格兰杰因果关系分析（GCA）对同侧M1和全脑的静息态fMRI数据进行分析，探讨三组之间的差异。我们的研究结果表明，从额顶叶皮层同病灶M1的影响减少在两个中风亚组和同病灶M1的感觉运动皮层的影响减少在CPH组比PPH组。与PPH组相比，CPH组病灶M1对病灶对小脑、病灶对上级顶叶对病灶M1的影响减弱，其GCA值与FMA评分呈正相关;相反，同侧M1对同侧额中回和颞中回的影响增强，其GCA值与FMA评分呈负相关。这项研究表明，在同病灶M1的偶然流的异常与中风手功能障碍的严重程度，提供有价值的信息，以了解缺陷的休息状态有效连接的运动执行和额顶运动控制网络在脑可塑性中风后。
The primary motor cortex (M1) is often abnormally recruited in stroke patients with motor disabilities. However, little is known about the alterations in the causal connectivity of M1 following stroke. The purpose of the present study was to investigate whether the effective connectivity of the ipsilesional M1 is disturbed in stroke patients who show different outcomes in hand motor function. 23 patients with left-hemisphere subcortical stroke were selected and divided into two subgroups: partially paralyzed hands (PPH) and completely paralyzed hands (CPH). Further, 24 matched healthy controls (HCs) were recruited. A voxel-wise Granger causality analysis (GCA) on the resting-state fMRI data between the ipsilesional M1 and the whole brain was performed to explore differences between the three groups. Our results showed that the influence from the frontoparietal cortices to ipsilesional M1 was diminished in both stroke subgroups and the influence from ipsilesional M1 to the sensorimotor cortices decreased greater in the CPH group than in the PPH group. Moreover, compared with the PPH group, the decreased influence from ipsilesional M1 to the contralesional cerebellum and from the contralesional superior parietal lobe to ipsilesional M1 were observed in the CPH group, and their GCA values were positively correlated with the FMA scores; Conversely, the increased influence from ipsilesional M1 to the ipsilesional middle frontal gyrus and middle temporal gyrus were observed, whose GCA values were negatively correlated with the FMA scores. This study suggests that the abnormalities of casual flow in the ipsilesional M1 are related to the severity of stroke-hand dysfunction, providing valuable information to understand the deficits in resting-state effective connectivity of motor execution and the frontoparietal motor control network during brain plasticity following stroke.
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