Heat acclimation does not attenuate hepcidin elevation after a single session of endurance exercise under hot condition.
Heat acclimation does not attenuate hepcidin elevation after a single session of endurance exercise under hot condition.
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DOI：
10.1007/s00421-022-04974-8
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发表时间：
2022-08
影响因子：
3
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中科院分区：
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我们试图确定热适应对炎热条件下耐力运动引起的铁调素升高的影响。 15 名健康男性被分为两组：炎热条件下的耐力训练（HOT，35°C，n = 8）和凉爽条件下的耐力训练（CON，18°C，n = 7）。所有受试者均完成了 10 天的耐力训练（总共 8 节），其中包括在指定环境条件下以最大摄氧量 () 的 50% 进行 60 分钟的连续运动。受试者在训练前（HST 前）和训练后（HST 后）完成热应激运动测试（HST，60 分钟运动强度 60%），以评估炎热条件 (35°C) 下运动引起的体温调节和铁调素反应。与 HST 前相比，HOT 组运动期间 HST 后的核心温度显着降低（P = 0.004），但 CON 组则没有。 HOT 组和 CON 组在 HST 前表现出运动引起的血浆白细胞介素 6 (IL-6) 升高 (P = 0.002)。两组在 HST 后运动诱发的 IL-6 增加均显着减弱；然而，运动引起的 IL-6 升高的减少在两组之间没有显着差异。两组在HST前和HST后血清铁调素浓度均显着升高（P = 0.001），但在每次测试期间或整个研究期间，两组之间均未观察到显着差异。炎热条件下 10 天的耐力训练改善了体温调节，而训练后，炎热条件下运动引起的铁调素升高并未减弱。
We sought to determine the effects of heat acclimation on endurance exercise-induced hepcidin elevation under hot conditions. Fifteen healthy men were divided into two groups: endurance training under hot conditions (HOT, 35 °C, n = 8) and endurance training under cool conditions (CON, 18 °C, n = 7). All subjects completed 10 days of endurance training (8 sessions in total), consisting of 60 min of continuous exercise at 50% of maximal oxygen uptake () under their assigned environment condition. Subjects completed a heat stress exercise test (HST, 60 min exercise at 60% ) to evaluate the exercise-induced thermoregulatory and hepcidin responses under hot conditions (35 °C) before (pre-HST) and after (post-HST) the training period. Core temperature during exercise in the post-HST decreased significantly in the HOT group compared to pre-HST (P = 0.004), but not in the CON group. The HOT and CON groups showed augmented exercise-induced plasma interleukin-6 (IL-6) elevation in the pre-HST (P = 0.002). Both groups had significantly attenuated increases in exercise-induced IL-6 in the post-HST; however, the reduction of exercise-induced IL-6 elevation was not different significantly between both groups. Serum hepcidin concentrations increased significantly in the pre-HST and post-HST in both groups (P = 0.001), no significant difference was observed between both groups during each test or over the study period. 10 days of endurance training period under hot conditions improved thermoregulation, whereas exercise-induced hepcidin elevation under hot conditions was not attenuated following the training.
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影响因子：
3
作者：
Badenhorst, Claire E.;Dawson, Brian;Peeling, Peter
通讯作者：
Peeling, Peter
影响因子：
4
作者：
Lee BJ;Thake CD
通讯作者：
Thake CD
影响因子：
4
作者：
McKay, Alannah K. A.;Peeling, Peter;Burke, Louise M.
通讯作者：
Burke, Louise M.
DOI：
10.1249/mss.0b013e318192ce58
发表时间：
2009-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Peeling, Peter;Dawson, Brian;Trinder, Debbie
通讯作者：
Trinder, Debbie
影响因子：
3.3
作者：
Lorenzo, Santiago;Halliwill, John R.;Minson, Christopher T.
通讯作者：
Minson, Christopher T.