The catalytic subunit of the SWR1 remodeler is a histone chaperone for the H2A.Z-H2B dimer.
The catalytic subunit of the SWR1 remodeler is a histone chaperone for the H2A.Z-H2B dimer.
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DOI：
10.1016/j.molcel.2014.01.010
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发表时间：
2014-02-06
期刊：
影响因子：
16
通讯作者：
Bai, Yawen
中科院分区：
文献类型：
--
作者：
Hong, Jingjun;Feng, Hanqiao;Wang, Feng;Ranjan, Anand;Chen, Jianhong;Jiang, Jiansheng;Ghirlando, Rodolfo;Xiao, T. Sam;Wu, Carl;Bai, Yawen
Histone variant H2A.Z-containing nucleosomes exist at most eukaryotic promoters and play important roles in gene transcription and genome stability. The multi-subunit nucleosome-remodeling enzyme complex SWR1, conserved from yeast to mammals, catalyzes the ATP-dependent replacement of histone H2A in canonical nucleosomes with H2A.Z. How SWR1 catalyzes the replacement reaction is largely unknown. Here we determined the crystal structure of the N-terminal region (599–627) of the catalytic subunit Swr1, termed Swr1-Z domain, in complex with the H2A.Z-H2B dimer at 1.78 Å resolution. The Swr1-Z domain forms a 310 helix and an irregular chain. A conserved LxxLF motif in the Swr1-Z 310 helix specifically recognizes the αC helix of H2A.Z. Our results show that the Swr1-Z domain can deliver the H2A.Z-H2B dimer to the DNA-(H3–H4)2 tetrasome to form the nucleosome by a histone chaperone mechanism.
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影响因子：
9.9
作者：
Hua, Sujun;Kallen, Caleb B.;Dhar, Ruby;Baquero, Maria T.;Mason, Christopher E.;Russell, Beth A.;Shah, Parantu K.;Liu, Jiang;Khramtsov, Andrey;Tretiakova, Maria S.;Krausz, Thomas N.;Olopade, Olufunmilayo I.;Rimm, David L.;White, Kevin P.
通讯作者：
White, Kevin P.
影响因子：
64.5
作者：
Santisteban, MS;Kalashnikova, T;Smith, MM
通讯作者：
Smith, MM
DOI：
10.1007/bf00282226
发表时间：
1994-12-01
期刊：
MOLECULAR AND GENERAL GENETICS
影响因子：
--
作者：
CARR, AM;DORRINGTON, SM;NURSE, P
通讯作者：
NURSE, P
影响因子：
56.9
作者：
KORNBERG, RD;THOMAS, JO
通讯作者：
THOMAS, JO
影响因子：
14.9
作者：
Jackson, JD;Gorovsky, MA
通讯作者：
Gorovsky, MA