Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study.
Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study.
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DOI：
10.1007/s10552-014-0426-y
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发表时间：
2014-09
影响因子：
2.3
通讯作者：
John, Esther M.
中科院分区：
文献类型：
--
作者：
Slattery, Martha L.;Hines, Lisa H.;Lundgreen, Abbie;Baumgartner, Kathy B.;Wolff, Roger K.;Stern, Mariana C.;John, Esther M.
MAPK基因被与生长因子、激素和环境应激相关的多种因素激活。我们评估了1187名非西班牙裔白色（NHW）和1155名西班牙裔/美洲土著乳腺癌妇女中13个MAPK基因与生存率之间的关系。我们评估了饮食、生活方式和遗传祖先对这些关联的影响。美洲原住民（NA）血统的百分比由104个遗传信息标记确定。自适应秩截积（ARTP）用于确定基因和途径的意义。协会主要是在女性中观察到较低的NA血统。具体而言，MAPK通路与全因死亡率相关（PARTP=0.02），但与乳腺癌特异性死亡率无关（PARTP=0.10）。然而，MAP 2K 1和MAP 3 K9与乳腺癌特异性和全因死亡率相关。MAPK 12（PARTP=0.05）仅与乳腺癌特异性死亡率相关，MAP 3 K1（PARTP=0.02）和MAPK 1（PARTP=0.05）仅与全因死亡率相关。在具有较高NA血统的女性中，MAP 3 K2与全因死亡率显著相关（PARTP=0.04）。一些饮食和生活方式因素，包括饮酒，热量摄入，膳食叶酸和吸烟，显着修改与MAPK基因和全因死亡率的关联。我们的研究支持MAPK基因与乳腺癌诊断后生存率之间的相关性，特别是在低NA血统的女性中。MAPK通路中的遗传变异与所有女性的饮食和生活方式因素之间的相互作用支持了这些因素对乳腺癌生存率的重要作用。
MAPK genes are activated by a variety of factors related to growth factors, hormones, and environmental stress. We evaluated associations between 13 MAPK genes and survival among 1187 non-Hispanic white (NHW) and 1155 Hispanic/Native American women diagnosed with breast cancer. We assessed the influence of diet, lifestyle, and genetic ancestry on these associations. Percent Native American (NA) ancestry was determined from 104 Ancestry Informative Markers. Adaptive rank truncation product (ARTP) was used to determine gene and pathway significance. Associations were predominantly observed among women with lower NA ancestry. Specifically, the MAPK pathway was associated with all-cause mortality (PARTP=0.02), but not with breast cancer-specific mortality (PARTP=0.10). However, MAP2K1 and MAP3K9 were associated with both breast cancer-specific and all-cause mortality. MAPK12 (PARTP=0.05) was only associated with breast cancer-specific mortality, and MAP3K1 (PARTP=0.02) and MAPK1 (PARTP=0.05) were only associated with all-cause mortality. Among women with higher NA ancestry, MAP3K2 was significantly associated with all-cause mortality (PARTP=0.04). Several diet and lifestyle factors, including alcohol consumption, caloric intake, dietary folate, and cigarette smoking, significantly modified the associations with MAPK genes and all-cause mortality. Our study supports an association between MAPK genes and survival after diagnosis with breast cancer, especially among women with low NA ancestry. The interaction between genetic variation in the MAPK pathway with diet and lifestyle factors for all women supports the important role of these factors for breast cancer survivorship.
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影响因子：
45.3
作者：
Kwan, Marilyn L.;Kushi, Lawrence H.;Caan, Bette J.
通讯作者：
Caan, Bette J.
影响因子：
--
作者：
SLATTERY, ML;CAAN, BJ;KERBER, R
通讯作者：
KERBER, R
影响因子：
2.3
作者：
Wu, Anna H.;Gomez, Scarlett Lin;Vigen, Cheryl;Kwan, Marilyn L.;Keegan, Theresa H. M.;Lu, Yani;Shariff-Marco, Salma;Monroe, Kristine R.;Kurian, Allison W.;Cheng, Iona;Caan, Bette J.;Lee, Valerie S.;Roh, Janise M.;Sullivan-Halley, Jane;Henderson, Brian E.;Bernstein, Leslie;John, Esther M.;Sposto, Richard
通讯作者：
Sposto, Richard
DOI：
10.1080/01635581.2011.535963
发表时间：
2011
期刊：
Nutrition and cancer
影响因子：
--
作者：
Kim EH;Willett WC;Fung T;Rosner B;Holmes MD
通讯作者：
Holmes MD
影响因子：
3.8
作者：
Li, J;Ji, L
通讯作者：
Ji, L