Patterns of progressive atrophy vary with age in Alzheimer's disease patients.
Patterns of progressive atrophy vary with age in Alzheimer's disease patients.
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DOI：
10.1016/j.neurobiolaging.2017.11.002
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发表时间：
2018-03
影响因子：
4.2
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Fiford CM;Ridgway GR;Cash DM;Modat M;Nicholas J;Manning EN;Malone IB;Biessels GJ;Ourselin S;Carmichael OT;Cardoso MJ;Barnes J;Alzheimer's Disease Neuroimaging Initiative
年龄不仅是阿尔茨海默病（AD）的最大危险因素，也是疾病表现和进展的关键调节因素。在这里，我们研究了轻度认知障碍（MCI）和AD的纵向萎缩模式如何随年龄变化。数据包括153名AD、339名MCI和191名对照受试者的纵向1.5 t磁共振成像扫描。获得纵向体积变化的体素图，并在受试者之间对齐。然后根据诊断组和组与年龄之间的相互作用对局部体积变化进行建模，并根据总颅内体积、白质高强度体积和载脂蛋白E基因型进行调整。多重比较的家庭误差校正后，结果p < 0.05显著。按年龄分组的相互作用显示，年轻的AD患者在双侧楔前叶、顶叶和颞上叶的萎缩率明显更快。这些结果表明，年轻的AD患者主要是后侧进行性萎缩，无法解释白质高强度、载脂蛋白E或总颅内容积。临床试验可能受益于对平均年龄较低的患者群体采用结果测量，以捕获后皮质的进行性萎缩。
Age is not only the greatest risk factor for Alzheimer's disease (AD) but also a key modifier of disease presentation and progression. Here, we investigate how longitudinal atrophy patterns vary with age in mild cognitive impairment (MCI) and AD. Data comprised serial longitudinal 1.5-T magnetic resonance imaging scans from 153 AD, 339 MCI, and 191 control subjects. Voxel-wise maps of longitudinal volume change were obtained and aligned across subjects. Local volume change was then modeled in terms of diagnostic group and an interaction between group and age, adjusted for total intracranial volume, white-matter hyperintensity volume, and apolipoprotein E genotype. Results were significant at p < 0.05 with family-wise error correction for multiple comparisons. An age-by-group interaction revealed that younger AD patients had significantly faster atrophy rates in the bilateral precuneus, parietal, and superior temporal lobes. These results suggest younger AD patients have predominantly posterior progressive atrophy, unexplained by white-matter hyperintensity, apolipoprotein E, or total intracranial volume. Clinical trials may benefit from adapting outcome measures for patient groups with lower average ages, to capture progressive atrophy in posterior cortices.
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影响因子：
11
作者：
Frisoni, GB;Testa, C;Laakso, MP
通讯作者：
Laakso, MP
影响因子：
4.2
作者：
Barnes J;Carmichael OT;Leung KK;Schwarz C;Ridgway GR;Bartlett JW;Malone IB;Schott JM;Rossor MN;Biessels GJ;DeCarli C;Fox NC;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
DOI：
10.1136/jnnp-2016-314978
发表时间：
2017-11
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Harper L;Bouwman F;Burton EJ;Barkhof F;Scheltens P;O'Brien JT;Fox NC;Ridgway GR;Schott JM
通讯作者：
Schott JM
影响因子：
5.9
作者：
Evans, Matthew C.;Barnes, Josephine;Fox, Nick C.
通讯作者：
Fox, Nick C.
影响因子：
5.7
作者：
Jovicich, J;Czanner, S;Dale, A
通讯作者：
Dale, A