New insights into osteoporosis: the bone-fat connection.
New insights into osteoporosis: the bone-fat connection.
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DOI：
10.1111/j.1365-2796.2012.02564.x
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发表时间：
2012-10
影响因子：
11.1
通讯作者：
Rosen CJ
中科院分区：
文献类型：
--
作者：
Kawai M;de Paula FJ;Rosen CJ
Osteoporosis and obesity are chronic disorders that are increasing in prevalence. The pathophysiology of these diseases is multifactorial and includes genetic, environmental and hormonal determinants. Long considered as distinct disorders that rarely are found in the same individual, emerging evidence from basic and clinical studies support an important interaction between adipose tissue and the skeleton. Adiposity can influence bone remodeling through three possible mechanisms including secretion of cytokines that directly target bone, adipokines that influence the central nervous system thereby changing sympathetic impulses to bone, and paracrine influences on adjacent skeletal cells. This review will focus on our current understanding of bone-fat interactions and the clinical implications of recent studies linking obesity to osteoporosis.
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DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
通讯作者：
Miller KK
DOI：
10.1359/jbmr.090805
发表时间：
2010-02
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Ecklund K;Vajapeyam S;Feldman HA;Buzney CD;Mulkern RV;Kleinman PK;Rosen CJ;Gordon CM
通讯作者：
Gordon CM
影响因子：
64.5
作者：
Ferron M;Wei J;Yoshizawa T;Del Fattore A;DePinho RA;Teti A;Ducy P;Karsenty G
通讯作者：
Karsenty G
影响因子：
8.2
作者：
Coletta DK;Sriwijitkamol A;Wajcberg E;Tantiwong P;Li M;Prentki M;Madiraju M;Jenkinson CP;Cersosimo E;Musi N;Defronzo RA
通讯作者：
Defronzo RA
影响因子：
6.2
作者：
Devlin, Maureen J.;Cloutier, Alison M.;Thomas, Nishina A.;Panus, David A.;Lotinun, Sutada;Pinz, Ilka;Baron, Roland;Rosen, Clifford J.;Bouxsein, Mary L.
通讯作者：
Bouxsein, Mary L.