Stromal-cell and cancer-cell exosomes leading the metastatic exodus for the promised niche.
Stromal-cell and cancer-cell exosomes leading the metastatic exodus for the promised niche.
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DOI：
10.1186/bcr3426
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发表时间：
2013-06-18
期刊：
影响因子：
--
通讯作者：
Hoffman RM
中科院分区：
文献类型：
--
作者：
Hoffman RM
外泌体被认为在转移中起重要作用。Luga及其同事描述了基质细胞（如癌症相关成纤维细胞）产生外泌体，这些细胞被乳腺癌细胞吸收，然后装载Wnt 11，这与乳腺癌细胞的侵袭性和转移的刺激有关。先前的研究表明，乳腺癌细胞产生的外泌体被间质成纤维细胞和其他间质细胞占用，表明外泌体是癌症和间质细胞之间的串扰因子，以刺激转移。用荧光蛋白标记外泌体的成像将揭示外泌体促进转移的过程，包括转移前生态位的形成。
Exosomes are thought to play an important role in metastasis. Luga and colleagues have described the production of exosomes by stromal cells such as cancer-associated fibroblasts that are taken up by breast cancer cells and are then loaded with Wnt 11, which is associated with stimulation of the invasiveness and metastasis of the breast cancer cells. Previous studies have shown that exosomes produced by breast cancer cells are taken up by stromal fibroblasts and other stromal cells, suggesting that exosomes are agents of cross-talk between cancer and stromal cells to stimulate metastasis. Imaging of exosomes by labeling with fluorescent proteins will enlighten the process by which exosomes enhance metastasis, including premetastatic niche formation.
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影响因子：
64.5
作者：
Luga, Valbona;Zhang, Liang;Wrana, Jeffrey L.
通讯作者：
Wrana, Jeffrey L.
影响因子：
21.3
作者：
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影响因子：
14.8
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Raposo, Graca
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3.6
作者：
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通讯作者：
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