Hemiretinal form deprivation: evidence for local control of eye growth and refractive development in infant monkeys.
Hemiretinal form deprivation: evidence for local control of eye growth and refractive development in infant monkeys.
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DOI：
10.1167/iovs.08-3232
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发表时间：
2009-11
影响因子：
4.4
通讯作者：
Bockhorst KH
中科院分区：
文献类型：
--
作者：
Smith EL 3rd;Huang J;Hung LF;Blasdel TL;Humbird TL;Bockhorst KH
为了确定灵长类动物的屈光发育是否由局部视网膜机制介导，我们研究了半视网膜形态剥夺对恒河猴眼部生长和周围屈光模式的影响。从大约3周龄开始，9只小猴子戴着单眼扩散镜片（鼻场扩散镜片，NFD）饲养。对照数据来自未接受治疗的猴子、24只正常猴子和19只接受全视野扩散器（FFD）治疗的猴子。通过沿瞳孔轴和偏心率15度、30度和45度的视网膜镜检查评估屈光发展情况。分别通过a型超声扫描和磁共振成像（MRI）评估中心轴尺寸和眼形。半视网膜形式剥夺以区域选择性的方式改变屈光发育，通常在治疗的半视野中产生近视。特别是，6只NFD猴子表现出大量的鼻视野相对近视（- 1.81至- 9.00 D），在15度和30度鼻视野偏心率处最为明显。其他3只NFD猴子在处理区域表现出少量的相对远视。外周屈光的改变与治疗后半视网膜玻璃体腔深度的局部、区域特异性改变有关。形态剥夺对灵长类屈光发育和眼睛生长的影响是由一种机制介导的，可能是视网膜，它以一种空间受限的方式整合视觉信号，并在局部发挥其影响。
To determine whether refractive development in primates is mediated by local retinal mechanisms, we examined the effects of hemi-retinal form deprivation on ocular growth and the pattern of peripheral refractions in rhesus monkeys. Beginning at about 3 weeks of age, 9 infant monkeys were reared wearing monocular diffuser lenses that eliminated form vision in the nasal field (nasal field diffusers, NFD). Control data were obtained from the non-treated fellow eyes, 24 normal monkeys, and 19 monkeys treated with full-field diffusers (FFD). Refractive development was assessed by retinoscopy performed along the pupillary axis and at eccentricities of 15, 30 and 45 deg. Central axial dimensions and eye shape were assessed by A-scan ultrasonography and magnetic resonance imaging (MRI), respectively. Hemi-retinal form deprivation altered refractive development in a regionally selective manner, typically producing myopia in the treated hemi-fields. In particular, 6 of the NFD monkeys exhibited substantial amounts (−1.81 to −9.00 D) of relative myopia in the nasal field that were most obvious at the 15 and 30 deg nasal field eccentricities. The other 3 NFD monkeys exhibited small amounts of relative hyperopia in the treated field. The alterations in peripheral refraction were associated with local, region-specific alterations in vitreous chamber depth in the treated hemi-retina. The effects of form deprivation on refractive development and eye growth in primates are mediated by mechanisms, presumably retinal, that integrate visual signals in a spatially restricted manner and exert their influence locally.
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影响因子：
158.5
作者：
RAVIOLA, E;WIESEL, TN
通讯作者：
WIESEL, TN
影响因子：
1.8
作者：
Qiao-Grider, Ying;Hung, Li-Fang;Smith, Earl L., III
通讯作者：
Smith, Earl L., III
影响因子：
1.8
作者：
Kee, CS;Hung, LF;Smith, EL
通讯作者：
Smith, EL
影响因子：
1.8
作者：
NORTON, TT;RADA, JA
通讯作者：
RADA, JA
影响因子：
1.8
作者：
Bradley, DV;Fernandes, A;Boothe, RG
通讯作者：
Boothe, RG