Nanoporous membranes for medical and biological applications.
Nanoporous membranes for medical and biological applications.
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DOI：
10.1002/wnan.50
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发表时间：
2009-09
影响因子：
8.6
通讯作者：
Narayan, Roger J.
中科院分区：
文献类型：
--
作者：
Adiga, Shashishekar P.;Jin, Chunmin;Curtiss, Larry A.;Monteiro-Riviere, Nancy A.;Narayan, Roger J.
合成纳米多孔材料具有许多潜在的生物和医学应用，涉及分选、传感、分离和释放生物分子。被设计成模仿自然过滤系统的纳米多孔系统正在积极开发，用于智能植入式药物递送系统、生物人工器官和其他新型纳米启用医疗设备。纳米科学的最新进展使得精确控制纳米多孔材料中孔的形态以及物理和化学性质成为可能，这使得它们在分子水平上对调节和传感传输越来越有吸引力。在这项工作中，纳米多孔膜的生物医学应用的概述。各种在体内和体外膜的应用，包括生物传感，生物分选，免疫隔离和药物输送，提出。不同类型的纳米多孔材料和它们的制造技术进行了讨论，重点是有序孔膜。讨论了用于植入装置的膜的理想性能，包括生物相容性和抗生物污染行为。综述了利用表面改性技术改善纳米多孔膜功能的研究进展。尽管在纳米多孔材料的制造，表征和建模方面进行了广泛的研究，但仍然存在必须克服的几个挑战，以便创建表现类似于其生物对应物的合成纳米多孔系统。
Synthetic nanoporous materials have numerous potential biological and medical applications that involve sorting, sensing, isolating and releasing biological molecules. Nanoporous systems engineered to mimic natural filtration systems are actively being developed for use in smart implantable drug delivery systems, bioartificial organs, and other novel nano-enabled medical devices. Recent advances in nanoscience have made it possible to precisely control the morphology as well as physical and chemical properties of the pores in nanoporous materials that make them increasingly attractive for regulating and sensing transport at the molecular level. In this work, an overview of nanoporous membranes for biomedical applications is given. Various in vivo and in vitro membrane applications, including biosensing, biosorting, immunoisolation and drug delivery, are presented. Different types of nanoporous materials and their fabrication techniques are discussed with an emphasis on membranes with ordered pores. Desirable properties of membranes used in implantable devices, including biocompatibility and antibiofouling behavior, are discussed. The use of surface modification techniques to improve the function of nanoporous membranes is reviewed. Despite the extensive research carried out in fabrication, characterization, and modeling of nanoporous materials, there are still several challenges that must be overcome in order to create synthetic nanoporous systems that behave similarly to their biological counterparts.
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影响因子：
5.8
作者：
Åkerman, S;Viinikka, P;Paronen, P
通讯作者：
Paronen, P
影响因子：
3
作者：
Fissell, W. H.;Humes, H. D.;Roy, S.
通讯作者：
Roy, S.
影响因子：
64.8
作者：
Bayley, H;Cremer, PS
通讯作者：
Cremer, PS
DOI：
10.1073/pnas.93.24.13770
发表时间：
1996-11-26
影响因子：
11.1
作者：
Kasianowicz, JJ;Brandin, E;Deamer, DW
通讯作者：
Deamer, DW
影响因子：
7.4
作者：
HARRISON, DJ;TURNER, RFB;BALTES, HP
通讯作者：
BALTES, HP