Updates on Compositional MRI Mapping of the Cartilage: Emerging Techniques and Applications.
Updates on Compositional MRI Mapping of the Cartilage: Emerging Techniques and Applications.
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DOI：
10.1002/jmri.28689
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发表时间：
2023-07
影响因子：
4.4
通讯作者：
Regatte, Ravinder R. R.
中科院分区：
文献类型：
--
作者：
Zibetti, Marcelo V. W.;Menon, Rajiv G. G.;de Moura, Hector L. L.;Zhang, Xiaoxia;Kijowski, Richard;Regatte, Ravinder R. R.
关键词：
骨关节炎（OA）是一种广泛发生的退行性关节疾病，其严重地使人衰弱并且对社会造成显著的社会经济负担。磁共振成像（MRI）是软骨形态学评价的首选成像方式，因为它具有出色的软组织对比度和高空间分辨率。然而，其利用通常涉及软骨的主观定性评估。成分MRI是指使用各种MRI方法对软骨进行定量表征，可以提供有关早期OA期间发生的潜在成分和超微结构变化的重要信息。软骨成分MRI可以作为早期成像生物标志物，用于客观评估软骨，并有助于推动诊断，疾病表征和对新疗法的反应。本综述将总结当前和正在进行的最先进的软骨成分MRI技术，并重点介绍软骨成分MRI的新兴方法，包括MR指纹识别，压缩感知，多指数弛豫，改进和强大的射频脉冲序列，以及基于深度学习的采集，重建和分割。该综述还将简要讨论目前的挑战和未来的方向，采用这些新兴的软骨成分MRI技术用于临床实践和翻译OA研究。
Osteoarthritis (OA) is a widely occurring degenerative joint disease that is severely debilitating and causes significant socioeconomic burdens to society. Magnetic resonance imaging (MRI) is the preferred imaging modality for the morphological evaluation of cartilage due to its excellent soft tissue contrast and high spatial resolution. However, its utilization typically involves subjective qualitative assessment of cartilage. Compositional MRI, which refers to the quantitative characterization of cartilage using a variety of MRI methods, can provide important information regarding underlying compositional and ultrastructural changes that occur during early OA. Cartilage compositional MRI could serve as early imaging biomarkers for the objective evaluation of cartilage and help drive diagnostics, disease characterization, and response to novel therapies. This review will summarize current and ongoing state-of-the-art cartilage compositional MRI techniques and highlight emerging methods for cartilage compositional MRI including MR fingerprinting, compressed sensing, multi-exponential relaxometry, improved and robust radio-frequency pulse sequences, and deep learning-based acquisition, reconstruction, and segmentation. The review will also briefly discuss the current challenges and future directions for adopting these emerging cartilage compositional MRI techniques for use in clinical practice and translational OA research studies.
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DOI：
10.2214/ajr.20.24172
发表时间：
2021-06
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Chaudhari AS;Grissom MJ;Fang Z;Sveinsson B;Lee JH;Gold GE;Hargreaves BA;Stevens KJ
通讯作者：
Stevens KJ
影响因子：
5.2
作者：
通讯作者：
--
影响因子：
7
作者：
Bittersohl, B.;Miese, F. R.;Zilkens, C.
通讯作者：
Zilkens, C.
影响因子：
2.5
作者：
Deng, Xiang;Farley, Michelle;Burstein, Deborah
通讯作者：
Burstein, Deborah
影响因子：
3.3
作者：
Bieri, Oliver;Ganter, Carl;Scheffler, Klaus
通讯作者：
Scheffler, Klaus