Emotion-related brain organization and behavioral responses to socioemotional stimuli in pediatric cancer survivors with posttraumatic stress symptoms.
Emotion-related brain organization and behavioral responses to socioemotional stimuli in pediatric cancer survivors with posttraumatic stress symptoms.
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DOI：
10.1002/pbc.27470
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发表时间：
2019-01
影响因子：
3.2
通讯作者：
Rabinak CA
中科院分区：
文献类型：
--
作者：
Marusak HA;Iadipaolo AS;Paulisin S;Harper FW;Taub JW;Dulay K;Elrahal F;Peters C;Sala-Hamrick K;Crespo LM;Rabinak CA
儿童癌症对儿童及其家庭来说是一种改变生活的压力体验。虽然大多数儿童在心理上适应良好，但有一个重要的子集报告了创伤后应激症状（PTSS），近75%的儿童重新经历了癌症和/或其治疗的创伤部分。然而，很少有研究检查儿科癌症和相关PTSS对情绪处理的影响，以及对大脑中关键情绪中心的功能特性的影响（例如，杏仁核）。我们检查了17名儿童癌症幸存者（6-11岁）和17名年龄和性别匹配的对照组的癌症相关PTSS，情绪处理任务期间的行为反应，以及杏仁核的静息状态功能连接。癌症幸存者，相对于对照组，更有可能评级模糊（即，中性）面作为负（即，“消极偏见”）。较高的再体验PTSS与对中性面孔的更快反应相关。虽然在杏仁核中心性方面没有组间差异，但在幸存者中，较高的再体验PTSS和较快的反应时间都与杏仁核中心性的增加相关--杏仁核是一种与大脑信息处理中心相关的功能特性。在一项探索性中介分析中，我们发现杏仁核中心性介导了反应时间和PTSS之间的联系，这表明大脑的变化可能是情绪相关神经元学表达的近端标记。癌症幸存者的消极偏见可能反映了他们对癌症和/或其治疗的压力经历。这种消极偏见可能代表了对情绪相关大脑功能变化的敏感性，这反过来可能导致PTSS。
Pediatric cancer is a life-changing, stressful experience for children and their families. Although most children adjust well, psychologically, a significant subset report posttraumatic stress symptoms (PTSS), with nearly 75% re-experiencing traumatic parts of cancer and/or its treatment. However, little research has examined the effects of pediatric cancer and related PTSS on emotional processing, and on functional properties of key emotional centers in the brain (e.g., amygdala). We examined cancer-related PTSS, behavioral responses during an emotion-processing task, and resting-state functional connectivity of the amygdala in 17 pediatric cancer survivors (ages 6–11) and 17 age- and sex-matched controls. Cancer survivors, relative to controls, were more likely to rate ambiguous (i.e., neutral) faces as negative (i.e., “negativity bias”). Higher re-experiencing PTSS was associated with faster responses to neutral faces. Although there were no group differences in amygdala centrality, within survivors, both higher re-experiencing PTSS and faster reaction times were associated with increased centrality of the amygdala – a functional property associated with hubs of information processing in the brain. In an exploratory mediation analysis, we found that amygdala centrality mediated the link between reaction time and PTSS, suggesting that changes in the brain may be a proximal marker of the expression of emotion-related symptomology. Negativity bias in cancer survivors may reflect their stressful experiences with cancer and/or its treatment. This negativity bias may represent a susceptibility to changes in emotion-related brain functioning which may, in turn, lead to PTSS.
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影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
6.8
作者：
Marusak HA;Thomason ME;Peters C;Zundel C;Elrahal F;Rabinak CA
通讯作者：
Rabinak CA
影响因子：
4.2
作者：
Marusak HA;Zundel CG;Brown S;Rabinak CA;Thomason ME
通讯作者：
Thomason ME
DOI：
10.1016/s2352-3026(16)30110-7
发表时间：
2016-10
期刊：
The Lancet. Haematology
影响因子：
--
作者：
Cheung YT;Sabin ND;Reddick WE;Bhojwani D;Liu W;Brinkman TM;Glass JO;Hwang SN;Srivastava D;Pui CH;Robison LL;Hudson MM;Krull KR
通讯作者：
Krull KR
影响因子：
15.9
作者：
Ewers M;Sperling RA;Klunk WE;Weiner MW;Hampel H
通讯作者：
Hampel H