VIP and its homologues increase vascular conductance in certain endocrine and exocrine glands.
VIP and its homologues increase vascular conductance in certain endocrine and exocrine glands.
复制标题
VIP 及其同系物可增加某些内分泌腺和外分泌腺的血管传导性。
DOI：
10.1152/ajpendo.1988.254.4.e435
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Hedge,GA
中科院分区：
文献类型：
--
作者：
Huffman,LJ;Connors,JM;Hedge,GA
在麻醉雄性大鼠上研究了血管活性肠肽（VIP）及其结构类似物对组织血管电导的影响。VIP，肽组氨酸异亮氨酸（PHI），促胰液素，生长激素释放因子（GHRF），抑胃肽（GIP），或生理盐水静脉输注超过4分钟。组织血流量测定在此期间通过使用141铈标记的微球。对于输注过程中平均动脉血压的任何变化，将局部血流标准化，结果以组织血管电导（C）表示。在治疗前、治疗后20 min和2 h测定循环促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）水平。显着增加甲状腺，胰腺，和唾液腺血管Cs发生在肽输注与效力的顺序（VIP大于PHI大于分泌素大于GHRF大于GIP）与VIP的结构同源性的程度相关。PHI和促胰液素产生最大的增加血管Cs，这是与VIP获得的那些相同。循环TSH、T3和T4水平与生理盐水灌注大鼠在肽治疗后的值没有差异，肽治疗引起甲状腺血管C显着增加。在肾上腺、肾脏和睾丸中，VIP及其同系物对血管Cs几乎没有影响。我们随后测量了VIP输注过程中存在或不存在促胰液素的区域血管Cs。（250字处删节）
The effects of vasoactive intestinal peptide (VIP) and related structural homologues on tissue vascular conductances were investigated in anesthetized male rats. VIP, peptide histidine isoleucine (PHI), secretin, growth hormone-releasing factor (GHRF), gastric inhibitory peptide (GIP), or saline was infused intravenously over 4 min. Tissue blood flows were measured during this time by use of 141Ce-labeled microspheres. Regional blood flows were normalized for any change in mean arterial blood pressure during infusions, and results were expressed in terms of tissue vascular conductance (C). Circulating thyrotropin (TSH), triiodothyronine (T3), and thyroxine (T4) levels were determined before and at 20 min and 2 h after treatment. Marked increases in thyroid, pancreatic, and salivary gland vascular Cs occurred during peptide infusions with the order of potency (VIP greater than PHI greater than secretin greater than GHRF greater than GIP) correlating with the degree of structural homology to VIP. PHI and secretin produced maximal increases in vascular Cs, which were the same as those obtained with VIP. Circulating TSH, T3, and T4 levels were not different from values in saline-infused rats after peptide treatments that caused striking increases in thyroid vascular C. In the adrenal, kidney, and testis, VIP and its homologues had little to no effect on vascular Cs. We subsequently measured regional vascular Cs during VIP infusions in the presence or absence of secretin.(ABSTRACT TRUNCATED AT 250 WORDS)
登录
查看更多内容
血管活性肠肽与大鼠腮腺腺泡细胞上的特定受体结合，诱导淀粉酶分泌，并伴随细胞内环腺苷 3-5-单磷酸的积累。
影响因子：
4.8
作者：
Y. Inoue;K. Kaku;T. Kaneko;N. Yanaihara;T. Kanno
通讯作者：
T. Kanno
未提取的人血清中甲状腺素的免疫测定。
影响因子：
5.8
作者：
P. Larsen;J. Dočkalová;D. Sipula;F. Wu
通讯作者：
F. Wu
出血时肾上腺髓质和皮质血流。
影响因子：
--
作者：
M. Breslow;A. Mennen;R. Koehler;R. Traystman
通讯作者：
R. Traystman
猪胰腺对神经和激素刺激的分泌和血管反应
DOI：
10.1113/jphysiol.1970.sp009014
发表时间：
1970
期刊：
The Journal of Physiology
影响因子：
--
作者：
J. Hickson
通讯作者：
J. Hickson
与促胰液素、胰高血糖素和乙酰胆碱相比，评估血管活性肠肽 (VIP) 对狗唾液腺血流和唾液分泌的影响
影响因子：
7.3
作者：
T. Shimizu;N. Taira
通讯作者：
N. Taira