Sustained release d-amphetamine reduces cocaine but not 'speedball'-seeking in buprenorphine-maintained volunteers: a test of dual-agonist pharmacotherapy for cocaine/heroin polydrug abusers.
Sustained release d-amphetamine reduces cocaine but not 'speedball'-seeking in buprenorphine-maintained volunteers: a test of dual-agonist pharmacotherapy for cocaine/heroin polydrug abusers.
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DOI：
10.1038/npp.2010.175
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发表时间：
2010-12
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本研究的目的是确定口服缓释d-苯丙胺（SR-AMP）是否减少目前阿片类药物依赖和可卡因依赖的志愿者寻求可卡因和阿片类药物/可卡因组合（“快球”样）。在门诊丁丙诺啡（BUP）8 mg/天稳定后，无SR-AMP，8名参与者完成了为期3周的住院研究，继续BUP 8 mg/天维持和双盲递增SR-AMP每周剂量分别为0、30和60 mg/天。在每个SR-AMP每周剂量下稳定3天（Sat-Mon）后（0、15或30 mg，每天0700和1225给药），周二至周五早晨（0900-1200）参与者在双盲双模拟下以随机、平衡顺序抽样4种药物组合（鼻内可卡因和肌内氢吗啡酮）条件：可卡因（COC 100 mg +盐水）;氢吗啡酮（COC 4 mg + HYD 24 mg）;“Speedball”（COC 100 mg + HYD 24 mg）;和安慰剂（COC 4 mg +盐水）。这些药物组合的主观和生理效果进行了测量。从1230-1530，参与者可以选择12次试验的渐进比例计划，以获得药物单位（上午总剂量的1/12）或货币单位（2美元）。SR-AMP显著降低了COC，但没有HYD或速度球，选择和断点。SR-AMP还显著降低COC主观（例如滥用相关）效应，并且不增强COC诱导的心血管反应。这项研究表明，SR-AMP能够减弱COC自我管理，以及其选择性，在可卡因/海洛因多药滥用者。进一步的研究是必要的，以确定是否SR-AMP联合BUP可能是一个有用的双激动剂药物治疗。
The aim of this study was to determine whether oral sustained release d-amphetamine (SR-AMP) reduces cocaine and opioid/cocaine combination (‘speedball’-like) seeking in volunteers with current opioid dependence and cocaine dependence. Following outpatient buprenorphine (BUP) 8mg/day stabilization without SR-AMP, 8 participants completed a 3-week inpatient study with continued BUP 8 mg/day maintenance and double-blind ascending SR-AMP weekly doses of 0, 30 and 60 mg/day, respectively. After 3 days (Sat–Mon) stabilization at each SR-AMP weekly dose (0, 15 or 30 mg administered at 0700 and 1225 each day), on Tue–Fri mornings (0900–1200) participants sampled 4 drug combinations in randomized, counterbalanced order under double-blind, double-dummy (intranasal cocaine and intramuscular hydromorphone) conditions: Cocaine (COC 100 mg + saline); Hydromorphone (COC 4 mg + HYD 24 mg); “Speedball” (COC 100 mg + HYD 24 mg); and Placebo (COC 4 mg + saline). Subjective and physiological effects of these drug combinations were measured. From 1230–1530, participants could respond on a choice, 12-trial progressive ratio schedule to earn drug units (1/12th of total morning dose) or money units ($2). SR-AMP significantly reduced COC, but not HYD or speedball, choices and breakpoints. SR-AMP also significantly reduced COC subjective (e.g. abuse-related) effects and did not potentiate COC-induced cardiovascular responses. This study demonstrates the ability of SR-AMP to attenuate COC self-administration, as well as its selectivity, in cocaine/heroin polydrug abusers. Further research is warranted to ascertain whether SR-AMP combined with BUP could be a useful dual-agonist pharmacotherapy.
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影响因子：
3.4
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