Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle.
Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle.
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DOI：
10.1098/rsob.120185
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发表时间：
2013-03-20
期刊：
影响因子：
5.8
通讯作者：
Pereira-Leal JB
中科院分区：
文献类型：
--
作者：
Hochegger H;Hégarat N;Pereira-Leal JB
有丝分裂纺锤体的正确组装和及时分解对于细胞分裂过程中基因组的繁殖至关重要。极光激酶在协调双极纺锤体建立、染色体排列和分离中发挥着核心作用。在大多数真核生物中，从变形虫到人类，Aurora 活性似乎在纺锤体极和着丝粒上都需要，并且这些活性通常在两个不同的 Aurora 旁系同源物之间分配，称为 Aurora A 和 B。Aurora 激酶的极地和赤道功能通常被分开考虑，Aurora A 主要参与中心体动力学，而 Aurora B 协调着丝粒附着和胞质分裂。然而，Aurora A 和 B 的双重失活会产生显着的协同作用，从而消除染色体分离。这表明这两种活动共同协调有丝分裂进展。因此，最近的证据表明，Aurora A 和 B 在中期纺锤体组装和后期分解中共同发挥作用。在这里，我们对极光的这些共享功能进行了展望，讨论了有丝分裂激酶家族的进化，并推测为什么纺锤体微管的两端可能需要极光激酶活性。
The correct assembly and timely disassembly of the mitotic spindle is crucial for the propagation of the genome during cell division. Aurora kinases play a central role in orchestrating bipolar spindle establishment, chromosome alignment and segregation. In most eukaryotes, ranging from amoebas to humans, Aurora activity appears to be required both at the spindle pole and the kinetochore, and these activities are often split between two different Aurora paralogues, termed Aurora A and B. Polar and equatorial functions of Aurora kinases have generally been considered separately, with Aurora A being mostly involved in centrosome dynamics, whereas Aurora B coordinates kinetochore attachment and cytokinesis. However, double inactivation of both Aurora A and B results in a dramatic synergy that abolishes chromosome segregation. This suggests that these two activities jointly coordinate mitotic progression. Accordingly, recent evidence suggests that Aurora A and B work together in both spindle assembly in metaphase and disassembly in anaphase. Here, we provide an outlook on these shared functions of the Auroras, discuss the evolution of this family of mitotic kinases and speculate why Aurora kinase activity may be required at both ends of the spindle microtubules.
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影响因子：
7.5
作者：
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通讯作者：
Earnshaw WC
影响因子：
3.7
作者：
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通讯作者：
Ladurner P
DOI：
10.1083/jcb.200710019
发表时间：
2008-04-21
期刊：
The Journal of cell biology
影响因子：
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作者：
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通讯作者：
Stukenberg PT
影响因子：
4
作者：
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通讯作者：
Kishimoto, Takeo
影响因子：
5.3
作者：
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通讯作者：
Van Dyke, Terry