Interactions between epinephrine, ascending vagal fibers, and central noradrenergic systems in modulating memory for emotionally arousing events.
Interactions between epinephrine, ascending vagal fibers, and central noradrenergic systems in modulating memory for emotionally arousing events.
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DOI：
10.3389/fnbeh.2012.00035
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发表时间：
2012
影响因子：
3
通讯作者：
Williams CL
中科院分区：
文献类型：
--
作者：
Chen CC;Williams CL
众所周知，暴露在情绪化事件中会启动外周与唤醒相关的激素肾上腺素的分泌。这些神经内分泌的变化和随后外周生理输出的增加在调节涉及记忆形成的大脑系统方面发挥了不可或缺的作用。血脑屏障对肾上腺素的不通透性是理解外周激素如何在大脑中启动神经化学变化从而导致有效记忆形成的重要障碍。这一障碍需要确定一条假定的通路，该通路能够将肾上腺素产生的生理变化传送到边缘结构，将唤醒和影响相关信息结合到记忆中。拟议研究的一个主要主题是，迷走神经的上升纤维可能代表了这种机制。通过评估上升迷走神经纤维在调节记忆中的作用来检验这一假设，这些反应是在通过操纵食欲刺激产生情绪唤醒的行为条件下学习的反应。在第二项研究中，采用迷走神经传入纤维的电生理记录和体内微透析相结合的方法，同时评估外周肾上腺素水平的升高如何影响迷走神经放电，以及随后杏仁基底外侧核去甲肾上腺素释放的增强。最后一项研究使用了c-fos和多巴胺β羟基酶(DBH)的双重免疫组织化学标记，以确定单独使用肾上腺素或刺激迷走神经的强度与实验1中改善记忆的强度相同，是否会在参与处理情绪事件记忆的大脑区域产生类似的神经元活动模式。这一系列研究的结果证实了迷走神经上升纤维的重要性，它是传递生理唤醒对大脑系统的外围影响的重要途径，大脑系统将新信息编码到记忆存储中。
It is well-established that exposure to emotionally laden events initiates secretion of the arousal-related hormone epinephrine in the periphery. These neuroendocrine changes and the subsequent increase in peripheral physiological output play an integral role in modulating brain systems involved in memory formation. The impermeability of the blood brain barrier to epinephrine represents an important obstacle in understanding how peripheral hormones initiate neurochemical changes in the brain that lead to effective memory formation. This obstacle necessitated the identity of a putative pathway capable of conveying physiological changes produced by epinephrine to limbic structures that incorporate arousal and affect related information into memory. A major theme of the proposed studies is that ascending fibers of the vagus nerve may represent such a mechanism. This hypothesis was tested by evaluating the contribution of ascending vagal fibers in modulating memory for responses learned under behavioral conditions that produce emotional arousal by manipulating appetitive stimuli. A combination of electrophysiological recording of vagal afferent fibers and in vivo microdialysis was employed in a second study to simultaneously assess how elevations in peripheral levels of epinephrine affect vagal nerve discharge and the subsequent potentiation of norepinephrine release in the basolateral amygdala. The final study used double immunohistochemistry labeling of c-fos and dopamine beta hydroxylase (DBH), the enzyme for norepinephrine synthesis to determine if epinephrine administration alone or stimulation of the vagus nerve at an intensity identical to that which improved memory in Experiment 1 produces similar patterns of neuronal activity in brain areas involved in processing memory for emotional events. Findings emerging from this collection of studies establish the importance of ascending fibers of the vagus nerve as an essential pathway for conveying the peripheral consequences of physiological arousal on brain systems that encode new information into memory storage.
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影响因子：
2.4
作者：
Cahill, L;McGaugh, JL
通讯作者：
McGaugh, JL
影响因子：
2.9
作者：
DEBOER, SF;DEBEUN, R;VANDERGUGTEN, J
通讯作者：
VANDERGUGTEN, J
影响因子：
3.4
作者：
Chang, CH;Liang, KC;Yen, CT
通讯作者：
Yen, CT
DOI：
10.1073/pnas.162356599
发表时间：
2002-08-06
影响因子：
11.1
作者：
Canli, T;Desmond, JE;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
8.2
作者：
FELDMAN, S;CONFORTI, N;WEIDENFELD, J
通讯作者：
WEIDENFELD, J