Polypeptide growth factors: roles in normal and abnormal cell growth.
Polypeptide growth factors: roles in normal and abnormal cell growth.
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多肽生长因子：在正常和异常细胞生长中的作用。
DOI：
10.1146/annurev.cb.03.110187.002303
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Deuel,TF
中科院分区：
文献类型：
--
作者：
Deuel,TF
越来越多的多肽生长因子已被确定，不仅调节细胞增殖，但非凡的细胞活动范围，包括基质蛋白沉积和分辨率，细胞活力的维持，细胞分化，炎症和组织修复。正常细胞似乎需要生长因子来增殖和维持活力。分泌多肽生长因子的细胞具有生长优势。这些因子可以通过细胞表面受体在外部起作用，也可以在受体和生长因子通过ER和高尔基体的运输过程中在内部起作用，引起细胞生长的自分泌刺激。根据细胞类型，生长因子也可以是细胞生长的有效抑制剂而不是刺激生长，并且效果可以取决于其他生长因子的存在或不存在。血小板衍生生长因子已被证明与猿猴肉瘤病毒的v-sis基因的产物几乎相同，其似乎通过其与PDGF受体的相互作用激活PDGF受体的酪氨酸激酶活性而引起细胞转化。类似地，两种原癌基因c-erbB和c-fms编码生长因子受体。v-erb癌基因产物的EGF受体活性似乎在不需要生长因子的情况下被组成性激活，这可能是因为在氨基末端的截短缺失了EGF结合结构域。通过生长因子刺激静止细胞诱导myc和fos蛋白，以及ras癌基因的p21产物作为肾上腺素能信号转导中间体的潜力，提供了这些途径对刺激细胞生长很重要的直接证据。由v-sis癌基因转化的细胞似乎总是带有PDGF细胞表面受体，这表明该癌基因对转化的PDGF受体具有特定的要求。相反，由v-erbB和v-fms癌基因转化的细胞不受EGF或CSF-1的刺激。因此，在这些情况下，相应受体的酪氨酸激酶活性似乎普遍表达。一些重大问题仍未得到解答。特别是，生长因子启动DNA合成途径的机制是什么？生长因子受体酪氨酸激酶的生理底物是什么？还需要相当大的努力来进一步确定不同生长因子的细胞特异性，特别是在完整组织内，并确定各种生长因子如何相互作用。（400字处截断摘要）
An increasing number of polypeptide growth factors have been identified that regulate not only cell proliferation but an extraordinary range of cell activities, including matrix protein deposition and resolution, the maintenance of cell viability, cell differentiation, inflammation, and tissue repair. Normal cells appear to require growth factors for proliferation and for maintenance of viability. Cells that secrete a polypeptide growth factor have an advantage in growth. These factors can act either externally through cell surface receptors or perhaps internally during the transport of receptors and growth factors through the ER and Golgi, causing autocrine stimulation of cell growth. Depending on the cell type, growth factors can also be potent inhibitors of cell growth rather than stimulating growth, and the effects can depend on the presence or absence of other growth factors. Platelet-derived growth factor has been shown to be nearly identical to the product of the v-sis gene of the simian sarcoma virus, which appears to cause cell transformation through its interactions with the PDGF receptor activating the tyrosine kinase activity of the PDGF receptor. Similarly, two proto-oncogenes, c-erbB and c-fms, encode growth factor receptors. The EGF receptor activity of the v-erb oncogene product appears to be constitutively activated without the need for growth factor, perhaps because of the truncation at the amino terminus deleting the EGF binding domain. The induction of the myc and the fos proteins by growth factor stimulation of quiescent cells, as well as the potential for the p21 product of the ras oncogene to act as an intermediate in transducing adrenergic signals, provide direct evidence that these pathways are important for stimulation of cell growth. Cells transformed by the v-sis oncogene always appear to bear PDGF cell surface receptors, which suggests that this oncogene has a specific requirement of the PDGF receptor for transformation. In contrast, cells transformed by the v-erbB and v-fms oncogenes are not stimulated by EGF or by CSF-1. Thus it seems likely that the tyrosine kinase activity of the corresponding receptor is ubiquitously expressed in these cases. Major questions remain unanswered. In particular, what are the mechanisms by which growth factors initiate pathways leading to DNA synthesis? What are the physiological substrates of the growth factor receptor tyrosine kinase? Considerable effort also is needed to further define the cellular specificity of the different growth factors, particularly within intact tissues, and to determine how the various growth factors interact.(ABSTRACT TRUNCATED AT 400 WORDS)
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DOI：
10.1016/0006-291x(82)91941-6
发表时间：
1982-01
影响因子：
3.1
作者：
A. Johnsson;C. Heldin;B. Westermark;Å. Wasteson
通讯作者：
A. Johnsson;C. Heldin;B. Westermark;Å. Wasteson
在培养的成纤维细胞中，血小板衍生生长因子对表皮生长因子（EGF）的有丝分裂反应。
影响因子：
3.7
作者：
Wharton,W;Leof,E;Olashaw,N;O'Keefe,EJ;Pledger,WJ
通讯作者：
Pledger,WJ
细菌中产生的 v-sis 癌基因蛋白会竞争与其受体结合的血小板衍生生长因子。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Wang,JY;Williams,LT
通讯作者：
Williams,LT
使用 A-431 膜对表皮生长因子刺激的磷酸化进行电泳表征。
影响因子：
2.9
作者：
L. King;G. Carpenter;S. Cohen
通讯作者：
S. Cohen
在静止的 Swiss 3T3 细胞中，蛋白激酶 C 的激活可快速引发离子反应。
DOI：
10.1073/pnas.82.8.2384
发表时间：
1985
影响因子：
11.1
作者：
F. Vara;J. Schneider;E. Rozengurt
通讯作者：
E. Rozengurt