The role of the primary auditory cortex in the neural mechanism of auditory verbal hallucinations.
The role of the primary auditory cortex in the neural mechanism of auditory verbal hallucinations.
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DOI：
10.3389/fnhum.2013.00144
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发表时间：
2013
影响因子：
2.9
通讯作者：
Hugdahl K
中科院分区：
文献类型：
--
作者：
Kompus K;Falkenberg LE;Bless JJ;Johnsen E;Kroken RA;Kråkvik B;Larøi F;Løberg EM;Vedul-Kjelsås E;Westerhausen R;Hugdahl K
听觉言语幻觉（AVH）是在环境中没有相应物理刺激的情况下“听到声音”的主观体验。AVH最显着的特征是它们的感知质量，也就是说，主观上的体验往往像听到实际的声音一样生动，而不是心理意象或听觉记忆。这导致了初级听觉皮层（PAC）的失调是AVH神经机制的重要组成部分的命题。PAC引起幻觉体验的一种可能机制是神经元活动的异常模式，PAC对内部处理引起的激活过度敏感，而对外部刺激的反应较低。在本文中，我们回顾了最近的研究有关的PAC在AVH的产生中的作用。我们提出了新的数据，从功能性磁共振成像（fMRI）研究，检查响应的左，右PAC的听觉言语刺激的强度参数调制，并相应的注意力自上而下的控制在非临床参与者AVH，和非临床参与者没有AVH。非临床幻觉者对语音的激活减少，但右PAC的注意力调节完好。此外，我们目前的数据，从一组精神分裂症患者AVH，谁不显示注意调制的左或右PAC。PAC的情境适当调制可能是非临床幻觉的保护因素。
Auditory verbal hallucinations (AVHs) are a subjective experience of “hearing voices” in the absence of corresponding physical stimulation in the environment. The most remarkable feature of AVHs is their perceptual quality, that is, the experience is subjectively often as vivid as hearing an actual voice, as opposed to mental imagery or auditory memories. This has lead to propositions that dysregulation of the primary auditory cortex (PAC) is a crucial component of the neural mechanism of AVHs. One possible mechanism by which the PAC could give rise to the experience of hallucinations is aberrant patterns of neuronal activity whereby the PAC is overly sensitive to activation arising from internal processing, while being less responsive to external stimulation. In this paper, we review recent research relevant to the role of the PAC in the generation of AVHs. We present new data from a functional magnetic resonance imaging (fMRI) study, examining the responsivity of the left and right PAC to parametrical modulation of the intensity of auditory verbal stimulation, and corresponding attentional top-down control in non-clinical participants with AVHs, and non-clinical participants with no AVHs. Non-clinical hallucinators showed reduced activation to speech sounds but intact attentional modulation in the right PAC. Additionally, we present data from a group of schizophrenia patients with AVHs, who do not show attentional modulation of left or right PAC. The context-appropriate modulation of the PAC may be a protective factor in non-clinical hallucinations.
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