Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms.
Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms.
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DOI：
10.1016/j.tem.2010.11.002
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发表时间：
2011-02
影响因子：
10.9
通讯作者：
Oldham, Sean
中科院分区：
文献类型：
--
作者：
Oldham, Sean
Obesity has grown to epidemic proportions globally, with 400 million considered obese. Evidence indicates that excessive dietary accumulation of lipids (obesity) is a risk factor in causing deleterious effects on metabolism and has been strongly linked to the progression of heart disease and Type 2 diabetes. Investigating the origin and effects of high fat diet (HFD)-induced obesity and its genetic mediators is an important step in understanding the mechanisms that contribute to obesity. However, the mechanisms that underlie HFD pathophysiology have yet to be fully elucidated. Here, we describe recent work in the Drosophila model to investigate the origin and genetic mechanisms that may underlie HFD-induced obesity, Type 2 diabetes, and cardiac dysfunction.
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