Prenatal lead exposure and weight of 0- to 5-year-old children in Mexico city.
Prenatal lead exposure and weight of 0- to 5-year-old children in Mexico city.
复制标题
DOI：
10.1289/ehp.1003184
复制
发表时间：
2011-10
影响因子：
10.4
通讯作者：
Téllez-Rojo MM
中科院分区：
文献类型：
--
作者：
Afeiche M;Peterson KE;Sánchez BN;Cantonwine D;Lamadrid-Figueroa H;Schnaas L;Ettinger AS;Hernández-Avila M;Hu H;Téllez-Rojo MM
背景：以母亲骨铅负荷衡量的产前累积铅暴露与出生时和1个月大的婴儿体重较轻有关，但还没有研究检验这种影响是否会持续到儿童早期。目的：探讨围产期母体骨铅累积暴露的生物标志物与儿童出生至5岁体重的关系。方法：婴儿出生时称体重，每隔一段时间称体重，直到60个月。产后1个月用活体K-shell X射线荧光法测定母体胫骨和髌骨铅含量。我们使用具有随机效应的变系数模型，评估了1994年至2005年在墨西哥城出生的522名男孩和477名女孩的体重轨迹与母亲骨铅的相关性。结果：在控制了母乳喂养持续时间、母亲的人体测量学和社会人口学特征后，在5岁时，母亲膝盖骨铅水平增加1-SD与女性体重下降130.9-g[95%可信区间(CI)-227.4-34.4g]和男性体重增加13.0g(95%CI，-73.7-99.9g)相关。在控制出生至5年间的同步血铅水平后，这些相关性相似。结论：在5岁以下的女性儿童中，随着时间的推移，母亲的骨铅与体重减轻有关，但与男性儿童的体重减轻无关。鉴于这种关联在膝盖骨而不是胫骨的铅水平上是明显的，而且仅限于女性，结果需要在其他研究中得到证实。
Background: Cumulative prenatal lead exposure, as measured by maternal bone lead burden, has been associated with smaller weight of offspring at birth and 1 month of age, but no study has examined whether this effect persists into early childhood. Objective: We investigated the association of perinatal maternal bone lead, a biomarker of cumulative prenatal lead exposure, with children’s attained weight over time from birth to 5 years of age. Methods: Children were weighed at birth and at several intervals up until 60 months. Maternal tibia and patella lead were measured at 1 month postpartum using in vivo K-shell X-ray fluorescence. We used varying coefficient models with random effects to assess the association of maternal bone lead with weight trajectories of 522 boys and 477 girls born between 1994 and 2005 in Mexico City. Results: After controlling for breast-feeding duration, maternal anthropometry, and sociodemographic characteristics, a 1-SD increase in maternal patella lead (micrograms per gram) was associated with a 130.9-g decrease in weight [95% confidence interval (CI), –227.4 to –34.4 g] among females and a 13.0-g nonsignificant increase in weight among males (95% CI, –73.7 to 99.9 g) at 5 years of age. These associations were similar after controlling for concurrent blood lead levels between birth and 5 years. Conclusions: Maternal bone lead was associated with lower weight over time among female but not male children up to 5 years of age. Given that the association was evident for patellar but not tibial lead levels, and was limited to females, results need to be confirmed in other studies.
登录
查看更多内容
影响因子：
8.3
作者：
Gulson, B;Mizon, K;Swan, H
通讯作者：
Swan, H
影响因子：
3.5
作者：
ANDREWS, KW;SAVITZ, DA;HERTZPICCIOTTO, I
通讯作者：
HERTZPICCIOTTO, I
影响因子：
1.6
作者：
GAMBLIN, C;GORDON, CL;WEBBER, CE
通讯作者：
WEBBER, CE
DOI：
10.1016/s0022-2143(97)90058-5
发表时间：
1997-07-01
期刊：
JOURNAL OF LABORATORY AND CLINICAL MEDICINE
影响因子：
--
作者：
Gulson, BL;Jameson, CW;Vimpani, G
通讯作者：
Vimpani, G
DOI：
10.1080/00039890209601441
发表时间：
2002-09-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Hernandez-Avila, M;Peterson, KE;Hu, H
通讯作者：
Hu, H