Association of Soluble Markers of Inflammation With Peri-coronary Artery Inflammation in People With and Without HIV Infection and Without Cardiovascular Disease.
Association of Soluble Markers of Inflammation With Peri-coronary Artery Inflammation in People With and Without HIV Infection and Without Cardiovascular Disease.
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DOI：
10.1093/ofid/ofad328
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发表时间：
2023-08
影响因子：
4.2
通讯作者：
中科院分区：
文献类型：
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作者：
炎症与接受抗逆转录病毒治疗（ART）的艾滋病毒感染者（PWH）的心血管疾病（CVD）风险升高有关。脂肪衰减指数（FAI）是衡量冠状动脉周围炎症的指标，可独立预测未感染HIV的人的CVD风险。FAI是否与可溶性炎症标志物相关尚不清楚。在58名PWH和16名对照组中测量了炎症标志物的血浆水平，这些对照组目前没有症状或既往已知的CVD，他们接受了冠状动脉计算机断层扫描血管造影术并进行了FAI测量。进行横断面分析，并使用多变量回归模型评估标志物与右冠状动脉（RCA）和左前降支（LAD）FAI值的相关性，调整潜在混杂因素年龄、性别、种族、低密度脂蛋白胆固醇、体重指数和降脂药物的使用。在校正模型中，几种炎症标志物与RCA或LAD FAI显著相关，包括sCD 14、sCD 163、TNFR-I和TNFR-II、CCL 5、CX 3CL 1、IP-10。全身性和冠状动脉周围炎症指数之间的关联是新颖的，并表明这些全身性标志物和FAI一起是有前途的非侵入性生物标志物，可用于评估无症状CVD患者与HIV感染者;它们也可能是评估抗炎干预措施效果的有用工具。
Inflammation is linked to elevated cardiovascular disease (CVD) risk in people with HIV (PWH) on antiretroviral therapy (ART). Fat attenuation index (FAI) is a measure of peri-coronary inflammation that independently predicts CVD risk in HIV-uninfected persons. Whether FAI is associated with soluble inflammatory markers is unknown. Plasma levels of inflammatory markers were measured in 58 PWH and 16 controls without current symptoms or prior known CVD who underwent coronary computed tomography angiography and had FAI measurements. A cross-sectional analysis was performed, and associations of markers with FAI values of the right coronary artery (RCA) and left anterior descending artery (LAD) were assessed using multivariable regression models adjusted for the potential confounders age, sex, race, low-density lipoprotein cholesterol, body mass index, and use of lipid-lowering medication. Several inflammatory markers had significant associations with RCA or LAD FAI in adjusted models, including sCD14, sCD163, TNFR-I, and TNFR-II, CCL5, CX3CL1, IP-10. The associations between indices of systemic and peri-coronary inflammation are novel and suggest that these systemic markers and FAI together are promising noninvasive biomarkers that can be applied to assess asymptomatic CVD in people with and without HIV; they also may be useful tools to evaluate effects of anti-inflammatory interventions.
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影响因子：
6.7
作者：
Panigrahi S;Chen B;Fang M;Potashnikova D;Komissarov AA;Lebedeva A;Michaelson GM;Wyrick JM;Morris SR;Sieg SF;Paiardini M;Villinger FJ;Harth K;Kashyap VS;Cameron MJ;Cameron CM;Vasilieva E;Margolis L;Younes SA;Funderburg NT;Zidar DA;Lederman MM;Freeman ML
通讯作者：
Freeman ML
DOI：
10.1097/qad.0000000000003125
发表时间：
2022-03-01
期刊：
AIDS (London, England)
影响因子：
--
作者：
Jeudy J;Patel P;George N;Burrowes S;Husson J;Chua J;Conn L;Weiss RG;Bagchi S
通讯作者：
Bagchi S
影响因子：
--
作者：
Vasilieva E;Gianella S;Freeman ML
通讯作者：
Freeman ML
影响因子：
3.8
作者：
Senoner, Thomas;Barbieri, Fabian;Feuchtner, Gudrun M.
通讯作者：
Feuchtner, Gudrun M.
影响因子：
--
作者：
van den Borne P;Quax PH;Hoefer IE;Pasterkamp G
通讯作者：
Pasterkamp G