Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition
Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition
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fat-1转基因小鼠内源合成的n-3多不饱和脂肪酸通过损害间充质到上皮的转化来抑制B16F10黑色素瘤肺转移
DOI：
10.1016/j.jff.2016.10.006
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发表时间：
2016-12
影响因子：
5.6
通讯作者：
Bu Shi-Zhong
中科院分区：
文献类型：
--
作者：
Zhu Pan;Zhang Yuan-Ming;Yin Xuan;Zhang Xiao-Hong;Wang Feng;Zhang Jin-Jie;Yan Wang;Xi Yang;Wan Jian-Bo;Kang Jing-Xuan;Zou Zu-Quan;Bu Shi-Zhong
Malignant melanoma is an aggressive cancer of neuroectodermal origin. The mechanisms of n-3 polyunsaturated fatty acids (PUFAs) against melanoma metastasis are not clear. Here fat-1 and wild type (WT) mice were injected with B16F10 melanoma cells via the tail vein to establish lung metastasis model. Endogenous n-3 PUFAs were associated with a reduction in grossly visible pulmonary metastases and outgrowth through inhibition of mesenchymal to epithelial transition (MET), which was characterized by decreased expression of epithelial markers E-cadherin and ZO-1, and increased expression of mesenchymal marker vimentin in tumour tissues from fat-1 mice compared with WT controls. In addition, n-3 PUFA-mediated inhibition of MET may have been associated, in part, with the: (i) formation of n-3 PUFA-derived lipid mediators and (ii) decreased expression of mature IL-1β and p-NF-κB, and enhanced expression of superoxide dismutase-1. These results suggest that n-3 PUFAs exert their antitumourigenic activities, in part, via their anti-inflammatory properties.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
DOI：
10.1016/j.chroma.2014.07.006
发表时间：
2014-09-12
期刊：
Journal of chromatography. A
影响因子：
--
作者：
Wang Y;Armando AM;Quehenberger O;Yan C;Dennis EA
通讯作者：
Dennis EA
DOI：
10.1016/j.plefa.2007.10.010
发表时间：
2007-11-01
影响因子：
3
作者：
Kang, Jing X.
通讯作者：
Kang, Jing X.
影响因子：
2.9
作者：
Funahashi, Hitoshi;Satake, Makoto;Eibl, Guido
通讯作者：
Eibl, Guido
影响因子：
2.7
作者：
Chaffer, Christine L.;Thompson, Erik W.;Williams, Elizabeth D.
通讯作者：
Williams, Elizabeth D.