Clinicopathological features and recurrence patterns of combined hepatocellular-cholangiocarcinoma.
Clinicopathological features and recurrence patterns of combined hepatocellular-cholangiocarcinoma.
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DOI：
10.1186/s12957-020-02099-w
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发表时间：
2020-12-04
影响因子：
3.2
通讯作者：
Uemoto S
中科院分区：
文献类型：
--
作者：
Ishii T;Ito T;Sumiyoshi S;Ogiso S;Fukumitsu K;Seo S;Taura K;Uemoto S
联合肝细胞胆管细胞癌是一种兼具肝细胞癌和胆管细胞癌成分的原发性肝癌。我们分析了CHCC-CCA的临床病理特征和复发模式。由于CHCC-CCA的罕见，其病因、临床病理特征以及与其他原发性肝癌相比的预后尚不清楚。它的复发模式和部位也需要特别阐明。本研究回顾了2005-2015年间因原发性肝脏恶性肿瘤而行肝切除术的所有患者。共施行肝切除894例。16例患者中19例(2.1%)为CHCC-CCA。3例再次行肝切除术。CHCC-CCA的肝炎病毒背景和肿瘤标志物模式与肝细胞癌相似，与肝内CCA不同。胆道侵犯多见于CHCC-CCA和ICCA。CHCC-CCA、HCC和ICCA患者的5年总生存率分别为44.7%、56.6%和38.5%。CHCC-CCA、HCC和ICCA患者的5年无复发生存率分别为12.2%、28.7%和32.9%。肝脏是最常见的复发部位。然而，与肝细胞癌不同的是，在CHCC-CCA和ICCA中，淋巴结是第二常见的复发部位。6例患者获得了复发病变的病理标本，其中4例经病理证实为CHCC-CCA复发。CHCC-CCA融合了肝癌和ICCA的特点。许多CHCC-CCA病例即使在复发后病理上仍保持CHCC-CCA。
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a primary liver carcinoma with both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) components. We examined the clinicopathological characteristics and recurrence patterns of cHCC-CCA. Because of the rarity of cHCC-CCA, its etiology, clinicopathological features, and prognosis in comparison with other primary liver carcinoma remain unknown. Its recurrence pattern and sites in particular also need to be elucidated. All patients who underwent hepatectomy for primary liver malignancies between 2005 and 2015 were retrospectively included in this study. Eight hundred and ninety-four hepatectomies were performed. Nineteen cases of cHCC-CCA (2.1%) in 16 patients were enrolled. Three patients underwent re-hepatectomy. The background of hepatitis viruses and tumor marker patterns of cHCC-CCA were similar to those of HCC and dissimilar to those of intrahepatic CCA (iCCA). Biliary invasion was common in cHCC-CCA and iCCA. The 5-year overall survival values of the cHCC-CCA, HCC, and iCCA patients were 44.7%, 56.6%, and 38.5%, respectively. The 5-year recurrence-free survival values of the cHCC-CCA, HCC, and iCCA patients were 12.2%, 28.7%, and 32.9%, respectively. The liver was the most common recurrence site. Unlike HCC, however, the lymph node was the second-most common recurrence site in both cHCC-CCA and iCCA. Pathological samples of the recurrent lesions were obtained in six patients, and four had cHCC-CCA recurrence pathologically. cHCC-CCA had a mixture of characteristics of HCC and iCCA. Many cases of cHCC-CCA remained cHCC-CCA pathologically even after recurrence.
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影响因子：
5.7
作者：
Kobayashi S;Terashima T;Shiba S;Yoshida Y;Yamada I;Iwadou S;Horiguchi S;Takahashi H;Suzuki E;Moriguchi M;Tsuji K;Otsuka T;Asagi A;Kojima Y;Takada R;Morizane C;Mizuno N;Ikeda M;Ueno M;Furuse J
通讯作者：
Furuse J
影响因子：
3.5
作者：
De Vito, Claudio;Sarker, Debashis;Quaglia, Alberto
通讯作者：
Quaglia, Alberto
影响因子：
2.6
作者：
Ye, J.;Xie, X.;Huang, G.
通讯作者：
Huang, G.
影响因子：
0.9
作者：
Wu, C. -H.;Yong, C-C.;Cheng, Y. -F.
通讯作者：
Cheng, Y. -F.
DOI：
10.1002/hep.29789
发表时间：
2018-07
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Brunt E;Aishima S;Clavien PA;Fowler K;Goodman Z;Gores G;Gouw A;Kagen A;Klimstra D;Komuta M;Kondo F;Miksad R;Nakano M;Nakanuma Y;Ng I;Paradis V;Nyun Park Y;Quaglia A;Roncalli M;Roskams T;Sakamoto M;Saxena R;Sempoux C;Sirlin C;Stueck A;Thung S;Tsui WMS;Wang XW;Wee A;Yano H;Yeh M;Zen Y;Zucman-Rossi J;Theise N
通讯作者：
Theise N