Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration.
Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration.
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DOI：
10.1002/adhm.202001305
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发表时间：
2021-04
影响因子：
10
通讯作者：
Swieszkowski W
中科院分区：
文献类型：
--
作者：
Rinoldi C;Kijeńska-Gawrońska E;Khademhosseini A;Tamayol A;Swieszkowski W
由创伤和退行性疾病引起的肌腱和韧带损伤是常见的，并且影响人口的不同群体。这种损伤降低了肌肉骨骼的性能，限制了关节的灵活性，并降低了人们的舒适度。目前，各种治疗策略和外科手术用于愈合、修复和恢复天然组织功能。然而，这些战略是不够的，在某些情况下，未能重新建立失去的功能。组织工程和再生医学方法旨在通过刺激新组织的再生和形成来克服这些缺点。设计和制造具有定制力学性能的人工支架对于恢复肌腱的力学功能至关重要。在这篇综述中，我们介绍了肌腱和韧带的结构，它们的生理和性能。另一方面，我们专注于开发有效重建设备的要求。我们还描述了肌腱和韧带组织再生最常见的纤维为基础的支架系统，如股纤维，编织，针织，编织，编织扭曲的纤维结构，以及静电纺和湿纺结构，严格讨论其利用的优点和局限性。最后，我们指出了潜在的多层系统作为肌腱和韧带组织工程的最有效的候选人。报告了用于肌腱和韧带修复、愈合和再生的基于纤维的系统的文献。纤维支架，包括股纤维，编织，针织，编织和编织扭曲的纤维结构，静电纺丝和湿纺结构，以及多层系统进行了严格的审查和描述，指出每种方法的优点和缺点。
Tendon and ligament injuries caused by trauma and degenerative diseases are frequent and affect diverse groups of the population. Such injuries reduce musculoskeletal performance, limit joint mobility, and lower people’s comfort. Currently, various treatment strategies and surgical procedures are used to heal, repair, and restore the native tissue function. However, these strategies are inadequate and, in some cases, fail to re-establish the lost functionality. Tissue engineering and regenerative medicine approaches aim to overcome these disadvantages by stimulating the regeneration and formation of neo-tissues. Design and fabrication of artificial scaffolds with tailored mechanical properties are crucial for restoring the mechanical function of tendons. In this review, we present the tendon and ligament structure, their physiology, and performance. On the other hand, we focus on the requirements for the development of an effective reconstruction device. We also describe the most common fiber-based scaffolding systems for tendon and ligament tissue regeneration like strand fibers, woven, knitted, braided, and braid-twisted fibrous structures, as well as electrospun and wet-spun constructs, discussing critically the advantages and limitations of their utilization. Finally, we point out the potential of multi-layered systems as the most effective candidates for tendon and ligaments tissue engineering. The literature of fiber-based systems for tendon and ligament repair, healing and regeneration is reported. Fibrous scaffolds including strand fibers, woven, knitted, braided and braid-twisted fibrous constructs, electrospun and wet-spun structures, as well as multi-layered systems are critically reviewed and described, pointing out advantages and drawbacks of each approach.
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影响因子：
3
作者：
Beason, David P.;Connizzo, Brianne K.;Bernstein, Joseph
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DOI：
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发表时间：
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影响因子：
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