Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer.
Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer.
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DOI：
10.1371/journal.pone.0129119
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Jordanova ES
中科院分区：
文献类型：
--
作者：
Punt S;Thijssen VL;Vrolijk J;de Kroon CD;Gorter A;Jordanova ES
半乳糖凝集素是结合 β-半乳糖苷糖的蛋白质，为癌症提供了一种新型的潜在生物标志物和治疗靶点。 Galectin-1、-3和-9已成为不同研究小组关注的焦点，但它们在宫颈癌中的表达和功能仍不清楚。本研究的目的是确定半乳糖凝集素-1、-3和-9表达细胞的表型以及与宫颈癌临床病理参数的关联。对鳞状宫颈癌的肿瘤细胞、肿瘤上皮浸润免疫细胞和基质细胞中的半乳糖凝集素表达进行评分（n = 160）。根据备注建议研究与临床病理参数和生存率的相关性。我们还研究了半乳糖凝集素是否由肿瘤细胞、成纤维细胞、巨噬细胞和 T 细胞表达。 11% 的样本中肿瘤细胞表达 Galectin-1 和 -9，而 84% 的样本表达 Galectin-3。肿瘤细胞的高半乳糖凝集素-1表达是生存不良的独立预测因素（风险比：8.02，p = 0.001），并且与肿瘤侵袭增加（p = 0.032）和接受术后放疗（p = 0.020）相关。肿瘤细胞半乳糖凝集素 3 的弱表达和阳性表达分别与肿瘤侵袭的增加和减少相关（p = 0.012）。半乳糖凝集素 9 的肿瘤细胞表达显示出生存率提高的趋势 (p = 0.087)。表达半乳糖凝集素-1、-3和-9的主要免疫细胞类型是CD163+巨噬细胞。 Galectin-1 和-3 由少数 T 细胞表达。 Galectin-1主要由肿瘤基质中的成纤维细胞表达。总之，虽然肿瘤细胞表达 galectin-9 似乎代表了有益的反应，但 galectin-1 表达可能被用作更积极的抗癌治疗的标志物。
Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9 have become the focus of different research groups, but their expression and function in cervical cancer is still unclear. The aim of this study was to determine the phenotype of galectin-1, -3 and -9 expressing cells and the association with clinico-pathological parameters in cervical cancer. Galectin expression was scored in tumor cells, tumor epithelium infiltrating immune cells and stromal cells in squamous cervical cancer (n = 160). Correlations with clinico-pathological parameters and survival were studied according to the REMARK recommendations. We additionally investigated whether the galectins were expressed by tumor cells, fibroblasts, macrophages and T cells. Galectin-1 and -9 were both expressed by tumor cells in 11% of samples, while 84% expressed galectin-3. Strong galectin-1 expression by tumor cells was an independent predictor for poor survival (hazard ratio: 8.02, p = 0.001) and correlated with increased tumor invasion (p = 0.032) and receiving post-operative radiotherapy (p = 0.020). Weak and positive tumor cell galectin-3 expression were correlated with increased and decreased tumor invasion, respectively (p = 0.012). Tumor cell expression of galectin-9 showed a trend toward improved survival (p = 0.087). The predominant immune cell type expressing galectin-1, -3 and -9 were CD163+ macrophages. Galectin-1 and -3 were expressed by a minor population of T cells. Galectin-1 was mainly expressed by fibroblasts in the tumor stroma. To conclude, while tumor cell expression of galectin-9 seemed to represent a beneficial response, galectin-1 expression might be used as a marker for a more aggressive anti-cancer treatment.
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DOI：
10.1016/j.bbadis.2013.12.003
发表时间：
2014-02-01
影响因子：
6.2
作者：
Heusschen, Roy;Schulkens, Iris A.;Thijssen, Victor L.
通讯作者：
Thijssen, Victor L.
影响因子：
3
作者：
Ochieng, J;Furtak, V;Lukyanov, P
通讯作者：
Lukyanov, P
影响因子：
45.3
作者：
Le, QT;Shi, GY;Koong, AC
通讯作者：
Koong, AC
DOI：
10.1016/j.ijrobp.2013.08.037
发表时间：
2013-12-01
影响因子：
7
作者：
Huang, Eng-Yen;Chanchien, Chan-Chao;Huang, Chao-Cheng
通讯作者：
Huang, Chao-Cheng
影响因子：
3
作者：
Hirashima, M;Kashio, Y;Nakamura, T
通讯作者：
Nakamura, T