Reactivation, replay, and preplay: how it might all fit together.
Reactivation, replay, and preplay: how it might all fit together.
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DOI：
10.1155/2011/203462
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发表时间：
2011
影响因子：
3.1
通讯作者：
Cheng S
中科院分区：
文献类型：
--
作者：
Buhry L;Azizi AH;Cheng S
在“离线”状态（例如睡眠或清醒休息）期间发生的神经元的顺序激活与在先前探索阶段期间记录的神经序列相关。这种所谓的再激活，或重放，已经在许多不同的大脑区域观察到，如纹状体，前额叶皮层，初级视觉皮层，最突出的是海马体。再激活主要与海马尖波/波纹、局部场电位中的短暂高频爆发共同发生。在这里，我们首先回顾了越来越多的证据，假设重新激活是睡眠期间记忆巩固的神经机制。然后，我们讨论最近的结果表明，离线连续活动在清醒状态下可能不是简单的重复以前经历的序列。一些离线序列活动发生在动物第一次暴露于新环境之前，并且一些离线激活的序列对应于动物从未经历过的轨迹。我们提出了一个概念框架的动态离线顺序活动，可以吝啬地描述了广泛的实验结果。这些结果表明，离线连续活动在认知功能中可能发挥更广泛的作用，例如维持空间表征，学习或规划。
Sequential activation of neurons that occurs during “offline” states, such as sleep or awake rest, is correlated with neural sequences recorded during preceding exploration phases. This so-called reactivation, or replay, has been observed in a number of different brain regions such as the striatum, prefrontal cortex, primary visual cortex and, most prominently, the hippocampus. Reactivation largely co-occurs together with hippocampal sharp-waves/ripples, brief high-frequency bursts in the local field potential. Here, we first review the mounting evidence for the hypothesis that reactivation is the neural mechanism for memory consolidation during sleep. We then discuss recent results that suggest that offline sequential activity in the waking state might not be simple repetitions of previously experienced sequences. Some offline sequential activity occurs before animals are exposed to a novel environment for the first time, and some sequences activated offline correspond to trajectories never experienced by the animal. We propose a conceptual framework for the dynamics of offline sequential activity that can parsimoniously describe a broad spectrum of experimental results. These results point to a potentially broader role of offline sequential activity in cognitive functions such as maintenance of spatial representation, learning, or planning.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
影响因子：
16.4
作者：
BOWER, GH
通讯作者：
BOWER, GH
影响因子：
64.8
作者：
Ekstrom, AD;Kahana, MJ;Fried, I
通讯作者：
Fried, I
影响因子：
2.9
作者：
BUZSAKI, G
通讯作者：
BUZSAKI, G
影响因子：
2.9
作者：
Cheng, S;Sabes, PN
通讯作者：
Sabes, PN