Reciprocal Interactions Between Regulatory T Cells and Intestinal Epithelial Cells.
Reciprocal Interactions Between Regulatory T Cells and Intestinal Epithelial Cells.
复制标题
调节性T细胞和肠上皮细胞之间的相互作用。
DOI：
10.3389/fimmu.2022.951339
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发表时间：
2022
影响因子：
7.3
通讯作者：
Wu, Chuan
中科院分区：
文献类型：
--
作者：
Jiang, Zhiqiang;Wu, Chuan
It has been well established that Foxp3+ regulatory T cells (Treg cells) play a crucial role for immune repression and tolerance, protecting the body from autoimmunity and inflammation. Previous studies indicate that intestinal Treg cells are one specialized population of Treg cells, distinct from those in other organ compartments, both functionally and phenotypically. Specific external and internal signals, particularly the presence of microbiota, shape these Treg cells to better cooperate with the gut ecosystem, controlling intestinal physiology. The integrity of intestinal epithelial barrier represents a key feature of gut immune tolerance, which can be regulated by multiple factors. Emerging evidence suggests that bidirectional interactions between gut epithelium and resident T cells significantly contribute to intestinal barrier function. Understanding how Treg cells regulate intestinal barrier integrity provides insights into immune tolerance-mediated mucosal homeostasis, which can further illuminate potential therapeutic strategies for treating inflammatory bowel disease and colon cancer.
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影响因子：
4.6
作者：
Goto Y;Lamichhane A;Kamioka M;Sato S;Honda K;Kunisawa J;Kiyono H
通讯作者：
Kiyono H
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
4.5
作者：
Gehlhaar A;Inala A;Llivichuzhca-Loja D;Silva TN;Adegboye CY;O'Connell AE;Konnikova L
通讯作者：
Konnikova L
影响因子：
4.6
作者：
Bae MJ;Shin HS;See HJ;Jung SY;Kwon DA;Shon DH
通讯作者：
Shon DH
影响因子：
5.5
作者：
Chen, Xiao;Song, Chun-Hua;Yang, Ping-Chang
通讯作者：
Yang, Ping-Chang