Hormone treatment and muscle anabolism during aging: androgens.
Hormone treatment and muscle anabolism during aging: androgens.
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DOI：
10.1016/j.clnu.2010.03.010
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Sheffield-Moore M
中科院分区：
文献类型：
--
作者：
Dillon EL;Durham WJ;Urban RJ;Sheffield-Moore M
衰老与男性循环睾酮浓度的逐渐下降和肌肉组织的减少有关。当出现性腺功能减退症的症状时，通常会考虑使用睾酮，但雄激素对肌肉生理的长期影响尚未完全了解。男性性腺功能减退症的定义仍然模糊，但通常是指总睾酮浓度低于300-500 ng/dL的阈值。雄激素替代疗法在内源性睾酮浓度低的男性和女性中通常是安全的。选择性雄激素受体调节剂（SARMs）的开发可能为性腺功能减退症的治疗提供额外的选择，同时降低长期使用雄激素通常相关的副作用的可能性。雄激素给药，无论是单独或与其他治疗相结合，可以成功地改善肌肉质量，通过增加蛋白质的摄入量和减少蛋白质的摄入量在男性和女性。进一步的研究是必要的，以优化雄激素的合成代谢和抗分解代谢特性，用于治疗和预防男性和女性的肌肉损失。
Aging is associated with a gradual decline in circulating testosterone concentrations and decreased musculature in men. While testosterone administration is often considered when symptoms of hypogonadism are presented, the long-term effects of androgen use on muscle physiology are not yet fully understood. The definition of hypogonadism in men remains obscure but is generally indicated by total testosterone concentrations less than a threshold value of 300-500 ng/dL. Androgen replacement therapy is generally safe in men and women with low endogenous testosterone concentrations. The development of selective androgen receptor modulators (SARMs) may provide additional options in treatment of hypogonadism while lowering the potential of side effects often associated with long-term androgen use. Androgen administration, either alone or in combination with other treatments, can be successful in improving muscle mass by increasing protein anabolism and reducing protein catabolism in men and women. Further research is necessary to optimize the anabolic and anticatabolic properties of androgens for treatment and prevention of muscle loss in men and women.
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DOI：
10.1093/gerona/56.5.m266
发表时间：
2001-05-01
影响因子：
5.1
作者：
Kenny, AM;Prestwood, KM;Raisz, LG
通讯作者：
Raisz, LG
影响因子：
5.8
作者：
Bhasin, S;Storer, TW;Casaburi, R
通讯作者：
Casaburi, R
影响因子：
4.8
作者：
Henderson, Gregory C.;Dhatariya, Ketan;Nair, K. Sreekumaran
通讯作者：
Nair, K. Sreekumaran
影响因子：
5.8
作者：
Cappola, Anne R.;Ratcliffe, Sarah J.;Fried, Linda P.
通讯作者：
Fried, Linda P.
影响因子：
7.1
作者：
Chapman, Ian M.;Visvanathan, Renuka;Horowitz, Michael
通讯作者：
Horowitz, Michael