Diabetes severity, metabolic syndrome, and the risk of erectile dysfunction.
Diabetes severity, metabolic syndrome, and the risk of erectile dysfunction.
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DOI：
10.1111/jsm.12318
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Leppert JT
中科院分区：
文献类型：
--
作者：
Weinberg AE;Eisenberg M;Patel CJ;Chertow GM;Leppert JT
勃起功能障碍（艾德）在患有2型糖尿病（T2 DM）、肥胖和/或代谢综合征（MetS）的男性中更常见。在具有全国代表性的美国数据样本中，研究糖尿病严重程度的替代指标与代谢综合征（MetS）和勃起功能障碍（艾德）之间的相关性。我们对2001-2004年国家健康和营养调查（NHANES）中的成年参与者进行了横断面分析。通过自我报告确定艾德。通过计算血糖控制和胰岛素抵抗（IR）指标定义T2 DM严重程度。采用空腹血浆胰岛素（FPI）水平和胰岛素抵抗的稳态模型评估（HOMA-IR）定义来估计胰岛素抵抗。我们使用HbA 1c和空腹血糖水平（FPG）对血糖控制进行分类。代谢综合征是由美国心脏协会和国家心脏，肺和血液研究所标准定义的。Logistic回归模型，调整了社会人口统计学，危险因素和合并症，适用于T2 DM严重程度，MetS和ED存在的每个测量。血糖控制和胰岛素抵抗的替代测量与ED相关。FPG在100- 126 mg/dL之间的参与者（5.6 ~ 7 mmol/L）和≥ 126 mg/dL（> 7 mmol/L）的患者发生艾德的危险度较高，OR值分别为1.22 [CI，0.83-1.80]和2.68 [CI，1.48-4.86]。HbA 1c 5.7-6.4%（38.8-46.4 mmol/mol）和≥6.5%（47.5 mmol/mol）的受试者发生艾德的几率较高（OR分别为1.73 [CI，1.08-2.76]和3.70 [CI，2.19-6.27]）。当FPI和HOMA-IR按三分位数进行评估时，最高三分位数的参与者之间存在等级关系。在多变量模型中，HbA 1c与艾德之间仍存在强相关性（OR 3.19 [CI，1.13 -9.01]）。MetS与自我报告的艾德的几率增加>2.5倍相关（OR 2.55 [CI，1.85-3.52]）。血糖控制不佳、胰岛素敏感性受损和代谢综合征与ED风险升高相关。
Erectile dysfunction (ED) is more common in men with type 2 diabetes mellitus (T2DM), obesity, and/or the metabolic syndrome (MetS). To investigate the associations among proxy measures of diabetic severity and the presence of metabolic syndrome (MetS) with erectile dysfunction (ED) in a nationally representative U.S. data sample. We performed a cross-sectional analysis of adult participants in the 2001–2004 National Health and Nutrition Examination Survey (NHANES). ED was ascertained by self-report. T2DM severity was defined by calculated measures of glycemic control and insulin resistance (IR). Insulin resistance was estimated using fasting plasma insulin (FPI) levels and the homeostasis model assessment of insulin resistance (HOMA-IR) definition. We classified glycemic control using HbA1c and fasting plasma glucose levels (FPG). Metabolic syndrome was defined by the American Heart Association and National Heart, Lung, and Blood Institute criteria. Logistic regression models, adjusted for sociodemographics, risk factors and comorbidities, were fitted for each measure of T2DM severity, MetS, and the presence of ED. Proxy measures of glycemic control and insulin resistance were associated with ED. Participants with FPG between 100–126mg/dL (5.6–7 mmol/L) and ≥126mg/dL (>7mmol/L) had higher odds of ED, OR 1.22 [CI, 0.83–1.80] and OR 2.68 [CI, 1.48–4.86], respectively. Participants with HbA1c 5.7–6.4% (38.8–46.4 mmol/mol) and ≥6.5% (47.5 mmol/mol) had higher odds of ED, (OR 1.73 [CI, 1.08–2.76] and 3.70 [CI, 2.19–6.27], respectively). When FPI and HOMA-IR were evaluated by tertiles, there was a graded relation among participants in the top tertile. In multivariable models, a strong association remained between HbA1c and ED (OR 3.19 [CI,1.13–9.01]). MetS was associated with >2.5-fold increased odds of self reported ED (OR 2.55 [CI, 1.85–3.52]). Poor glycemic control, impaired insulin sensitivity and the MetS are associated with a heightened risk of ED.
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影响因子：
8.9
作者：
Inman BA;Sauver JL;Jacobson DJ;McGree ME;Nehra A;Lieber MM;Roger VL;Jacobsen SJ
通讯作者：
Jacobsen SJ
影响因子：
3.5
作者：
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影响因子：
6.6
作者：
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影响因子：
3.5
作者：
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影响因子：
6.6
作者：
Heidler, Stefan;Temml, Christian;Ponholzer, Anton
通讯作者：
Ponholzer, Anton