Incorporation of carbon nanotubes in porous polymer monolithic capillary columns to enhance the chromatographic separation of small molecules.
Incorporation of carbon nanotubes in porous polymer monolithic capillary columns to enhance the chromatographic separation of small molecules.
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DOI：
10.1016/j.chroma.2011.02.055
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发表时间：
2011-05-06
期刊：
影响因子：
--
通讯作者：
Fréchet JM
中科院分区：
文献类型：
--
作者：
Chambers SD;Svec F;Fréchet JM
将多壁碳纳米管固定在聚甲基丙烯酸缩水甘油酯-二甲基丙烯酸乙二酯共聚物毛细管柱中，为反相中的小分子提供了具有更好的液相色谱性能的固定相。在不加纳米管的条件下，当L的流速为1和0.15时，加入少量的纳米管使聚合体系的效率分别提高到15,000和35,000板/m以上。或者，将天然的甲基丙烯酸缩水甘油酯整体柱用氨水功能化，然后，通过与胺官能团的静电相互作用，将带有羧基官能团的短碳纳米管连接到孔表面。减小整体柱的孔径使保留分析物苯的柱效提高到30,000板/米，流速为0.25min L/μ。在典型的乙腈水洗脱液中加入四氢呋喃改善了峰形，并将保留的苯峰的柱效提高到44,000板/米。
Multiwalled carbon nanotubes have been entrapped in monolithic poly(glycidyl methacrylate-co-ethylene dimethacrylate) capillary columns to afford stationary phases with enhanced liquid chromatographic performance for small molecules in the reversed phase. While the column with no nanotubes exhibited an efficiency of only 1800 plates/m, addition of a small amount of nanotubes to the polymerization mixture increased the efficiency to over 15,000 and 35,000 plates/m at flow rates of 1 and 0.15 μL/min, respectively. Alternatively, the native glycidyl methacrylate-based monolith was functionalized with ammonia and, then, shortened carbon nanotubes, bearing carboxyl functionalities, were attached to the pore surface through the aid of electrostatic interactions with the amine functionalities. Reducing the pore size of the monolith enhanced the column efficiency for the retained analyte, benzene, to 30,000 plates/m at a flow rate of 0.25 μL/min. Addition of tetrahydrofuran to the typical aqueous acetonitrile eluents improved the peak shape and increased the column efficiency to 44,000 plates/m calculated for the retained benzene peak.
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