Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease.
Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease.
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DOI：
10.1038/srep36797
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发表时间：
2016-11-09
影响因子：
4.6
通讯作者：
Cantacessi C
中科院分区：
文献类型：
--
作者：
Giacomin P;Zakrzewski M;Jenkins TP;Su X;Al-Hallaf R;Croese J;de Vries S;Grant A;Mitreva M;Loukas A;Krause L;Cantacessi C
胃肠道肠道微生物群多样性的减少与几种炎性疾病的发展有关。最近在人类和动物模型中的报道已经证明了寄生虫（蠕虫）感染在一些炎性疾病（例如炎性肠病（IBD）和乳糜泻（CeD））中的有益治疗效果。有趣的是，这些研究描述了蠕虫如何改变肠道微生物群，可能代表了它们调节炎症的机制。然而，出于实际原因，这些报告主要分析了粪便微生物群。在本研究中，我们首次使用十二指肠活检组织评估了CeD患者感染寄生蠕虫（钩虫）和麸质依赖性炎症部位微生物群的变化。钩虫感染和麸质暴露与拟杆菌门内物种丰度的增加以及肠道内组织驻留微生物群的丰富性和多样性的增加有关，这些结果与先前在人类和动物模型中使用其他蠕虫物种的报告一致。因此，这可能代表了寄生蠕虫可以恢复肠道免疫稳态并在CeD和潜在的其他炎症性疾病中发挥治疗益处的机制。
A reduced diversity of the gastrointestinal commensal microbiota is associated with the development of several inflammatory diseases. Recent reports in humans and animal models have demonstrated the beneficial therapeutic effects of infections by parasitic worms (helminths) in some inflammatory disorders, such as inflammatory bowel disease (IBD) and coeliac disease (CeD). Interestingly, these studies have described how helminths may alter the intestinal microbiota, potentially representing a mechanism by which they regulate inflammation. However, for practical reasons, these reports have primarily analysed the faecal microbiota. In the present investigation, we have assessed, for the first time, the changes in the microbiota at the site of infection by a parasitic helminth (hookworm) and gluten-dependent inflammation in humans with CeD using biopsy tissue from the duodenum. Hookworm infection and gluten exposure were associated with an increased abundance of species within the Bacteroides phylum, as well as increases in the richness and diversity of the tissue-resident microbiota within the intestine, results that are consistent with previous reports using other helminth species in humans and animal models. Hence, this may represent a mechanism by which parasitic helminths may restore intestinal immune homeostasis and exert a therapeutic benefit in CeD, and potentially other inflammatory disorders.
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影响因子：
14.9
作者：
Klindworth A;Pruesse E;Schweer T;Peplies J;Quast C;Horn M;Glöckner FO
通讯作者：
Glöckner FO
蠕虫和微生物群：卫生假设的一部分。
影响因子：
2.2
作者：
Loke P;Lim YA
通讯作者：
Lim YA
影响因子：
3.7
作者：
Laurence M;Hatzis C;Brash DE
通讯作者：
Brash DE
影响因子：
32.4
作者：
Dorrestein PC;Mazmanian SK;Knight R
通讯作者：
Knight R
DOI：
10.1098/rstb.2014.0296
发表时间：
2015-08-19
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Giacomin P;Croese J;Krause L;Loukas A;Cantacessi C
通讯作者：
Cantacessi C