Obese children show hyperactivation to food pictures in brain networks linked to motivation, reward and cognitive control.
Obese children show hyperactivation to food pictures in brain networks linked to motivation, reward and cognitive control.
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DOI：
10.1038/ijo.2010.84
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Savage CR
中科院分区：
文献类型：
--
作者：
Bruce AS;Holsen LM;Chambers RJ;Martin LE;Brooks WM;Zarcone JR;Butler MG;Savage CR
探讨儿童和青少年食物动机的神经机制，并检查健康体重（HW）和肥胖参与者之间的大脑激活差异。10名HW儿童（年龄11-16岁; BMI < 85%ile）和10名肥胖儿童（年龄10-17岁; BMI > 95%ile）在年龄、性别和受教育年限方面相匹配。功能性磁共振成像（fMRI）扫描进行了两次：当参与者饥饿时（餐前）和标准餐后立即（餐后）。在fMRI扫描过程中，参与者被动地观看食物，非食物（动物）和模糊基线对照的图像。两组儿童的边缘系统和边缘旁系统（PFC/OFC）对食物图像都表现出大脑激活。肥胖组在食物图片的PFC（餐前）和OFC（餐后）比HW组表现出更大的激活。此外，肥胖组餐后PFC、边缘系统和奖励处理区域（包括丘脑核）的激活减少较少（与餐前相比）。在两组参与者中，注意到高食物动机状态下的边缘系统和边缘系统激活。然而，与HW儿童相比，肥胖儿童对食物刺激反应过度。此外，与HW儿童不同，肥胖儿童对食物刺激的大脑激活在进食后未能显着减少。这项研究提供了初步的证据表明，肥胖，即使在儿童中，与参与食物动机的神经网络异常有关，并且与肥胖相关的神经回路功能障碍的起源可能在生命的早期开始。
To investigate the neural mechanisms of food motivation in children and adolescents, and examine brain activation differences between healthy weight (HW) and obese participants. Ten HW children (ages 11–16; BMI < 85%ile) and 10 obese children (ages 10–17; BMI > 95%ile) matched for age, gender and years of education. Functional magnetic resonance imaging (fMRI) scans were conducted twice: when participants were hungry (pre-meal) and immediately after a standardized meal (post-meal). During the fMRI scans, the participants passively viewed blocked images of food, non-food (animals) and blurred baseline control. Both groups of children showed brain activation to food images in the limbic and paralimbic regions (PFC/OFC). The obese group showed significantly greater activation to food pictures in the PFC (pre-meal) and OFC (post-meal) than the HW group. In addition, the obese group showed less post-meal reduction of activation (vs pre-meal) in the PFC, limbic and the reward-processing regions, including the nucleus accumbens. Limbic and paralimbic activation in high food motivation states was noted in both groups of participants. However, obese children were hyper-responsive to food stimuli as compared with HW children. In addition, unlike HW children, brain activations in response to food stimuli in obese children failed to diminish significantly after eating. This study provides initial evidence that obesity, even among children, is associated with abnormalities in neural networks involved in food motivation, and that the origins of neural circuitry dysfunction associated with obesity may begin early in life.
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影响因子：
5.7
作者：
Holsen, LM;Zarcone, JR;Savage, CR
通讯作者：
Savage, CR
影响因子：
120.7
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL
影响因子：
1.9
作者：
LaBar, KS;Gitelman, DR;Mesulam, MM
通讯作者：
Mesulam, MM
影响因子：
7.7
作者：
Matsuda, M;Liu, YJ;Gao, JH
通讯作者：
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影响因子：
158.5
作者：
Baker, Jennifer L.;Olsen, Lina W.;Sorensen, Thorkild I. A.
通讯作者：
Sorensen, Thorkild I. A.