Biomarkers of Stress and Male Fertility.
Biomarkers of Stress and Male Fertility.
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DOI：
10.1007/s43032-022-00853-x
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发表时间：
2022-04
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影响因子：
--
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中科院分区：
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研究压力(通过唾液α-淀粉酶和皮质醇来衡量)是否会对男性生育力产生负面影响(通过精液参数、怀孕率和活产率来衡量)。参加男性、抗氧化剂和不孕症(MOXI)试验的男性前瞻性队列研究。112名不育男子在第一天早上提供了基线的唾液和精液样本。唾液样本分析了α-淀粉酶和皮质醇。夫妇尝试自然受孕(1-3个月)和克罗米芬/宫内人工授精(4-6个月)。应激相关生物标志物和精液参数包括DNA碎片之间的关联通过调整男性年龄的线性回归模型来评估。唾液水平在第80个百分位数被一分为二。使用卡方检验，比较高五分之一的夫妇和其余受试者的妊娠率/活产率。唾液中的α-淀粉酶水平与精液参数或DNA片段化无关。唾液皮质醇水平与DNA片段化或正常形态无关。唾液皮质醇每增加1个单位，精子总数增加1390万(95%可信区间：2.5，25.3)，活动精子总数增加990万(95%可信区间：3.2-16.6)。与较低值的男性相比，α-淀粉酶(27%和28%，p=0.96；23%和21%，p=0.87)或皮质醇(40%和26%，p=0.22；35%和19%，p=0.12)最高五分之一的男性夫妇怀孕率和活产率没有差异。高压力的生理措施可能不会损害男性因素不育男性的精液参数，但实际上会改善他们的精液参数。NCT02421887
To study if stress, as measured by salivary alpha-amylase and cortisol, negatively impacts male fertility, as measured by semen parameters, pregnancy and live birth rates. Prospective, cohort study of men enrolled in the Males, Antioxidants, and Infertility (MOXI) Trial. 112 infertile men provided first morning salivary and semen samples at baseline. Salivary samples were analyzed for alpha-amylase and cortisol. Couples attempted to conceive naturally (months 1-3) and with clomiphene citrate/intrauterine insemination (months 4-6). The association between stress related biomarkers and semen parameters including DNA fragmentation were assessed using linear regression models adjusting for male age. Salivary levels were dichotomized at the 80th percentile. Pregnancy/live birth rates in couples in the upper quintile were compared to remaining subjects using chi-square testing. Salivary levels of alpha-amylase were not associated with semen parameters or DNA fragmentation. Salivary cortisol levels were not correlated with DNA fragmentation or normal morphology. For every 1-unit increase in salivary cortisol, total sperm count increased by 13.9million (95%CI: 2.5, 25.3) and total motile sperm count increased by 9.9million (95%CI: 3.2-16.6). Couple pregnancy rates and live birth rates did not differ for males in the highest quintile of alpha-amylase (27% and 28%, p=0.96; 23% and 21%, p=0.87) or cortisol (40% and 26%, p=0.22; 35% and 19%, p=0.12), compared to males with lower values. Physiologic measures of high stress may not harm but actually improve semen parameters among men with male-factor infertility. NCT02421887
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影响因子：
6.1
作者：
Anderheim, L;Holter, H;Möller, A
通讯作者：
Möller, A
DOI：
10.1186/1477-7827-3-51
发表时间：
2005-09-27
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Akingbemi BT
通讯作者：
Akingbemi BT
影响因子：
6.1
作者：
Simon, L.;Liu, L.;Carrell, D. T.
通讯作者：
Carrell, D. T.
影响因子：
2.4
作者：
Bhongade, M. B.;Prasad, S.;Koner, B. C.
通讯作者：
Koner, B. C.
影响因子：
6.1
作者：
Ebbesen, S. M. S.;Zachariae, R.;Ingerslev, H. J.
通讯作者：
Ingerslev, H. J.