Periodontal disease is associated with gestational diabetes mellitus: a case-control study.
Periodontal disease is associated with gestational diabetes mellitus: a case-control study.
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DOI：
10.1902/jop.2009.090250
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发表时间：
2009-11
影响因子：
4.3
通讯作者：
Buekens P
中科院分区：
文献类型：
--
作者：
Xiong X;Elkind-Hirsch KE;Vastardis S;Delarosa RL;Pridjian G;Buekens P
很少有研究专门探讨牙周病和妊娠期糖尿病（GDM）之间的关系。本研究的目的是探讨是否产妇牙周病与妊娠期糖尿病。对美国巴吞鲁日妇女医院53例妊娠期糖尿病孕妇和106例非妊娠期糖尿病孕妇进行病例对照研究。牙周检查是由一名校准牙医进行的，该牙医对孕妇的糖尿病状况不知情。牙周炎定义为牙周探诊深度（PD）≥ 4 mm或临床附着丧失（CAL）≥ 4 mm，牙周病的严重程度以PD和CAL的四分位数表示，采用单因素分析和多因素Logistic回归分析牙周病与GDM的关系。牙周炎的百分比是77.4%的GDM妇女和57.5%的妊娠非GDM妇女，比值比（OR）和95%置信区间（CI）为2.5（1.2-5.3）。在调整了母亲年龄、产次、种族、婚姻状况、教育、家庭收入、吸烟、饮酒、妊娠期全身抗生素、糖尿病家族史、收入、牙科保险覆盖率和体重指数等混杂变量后，调整后的OR（95%CI）为2.6（1.1-6.1）。比较PD和CAL的最高至最低四分位数，GDM的校正OR（95% CI）为3.8（1.0-14.0）和4.5（1.2-16.9）。这项研究支持牙周病和GDM之间的关联的假设。
Few studies have specifically examined the relationship between periodontal disease and gestational diabetes mellitus (GDM). The objective of this study was to examine whether maternal periodontal disease is associated with GDM. A case-control study was conducted of 53 pregnant women with GDM and 106 pregnant women without GDM at Woman’s Hospital, Baton Rouge, USA. The periodontal examinations were performed by a calibrated dentist who was blinded on the diabetic status of the pregnant women. Periodontitis was defined as the presence of any site with a probing depth (PD) ≥ 4 mm or a clinical attachment loss (CAL) ≥ 4 mm. The severity of periodontal disease was measured in quartiles of PD and CAL. Univariable analysis and multivariable logistic regression were used to examine the relationships between periodontal disease and GDM. The percentage of periodontitis was 77.4% in women with GDM and 57.5% in pregnant non-GDM women, with an odds ratio (OR) and 95% confidence interval (CI) of 2.5 (1.2–5.3). After adjusting for confounding variables of maternal age, parity, race, marital status, education, family income, smoking, alcohol consumption, systemic antibiotics in pregnancy, family history of diabetes, income, dental insurance coverage and body mass index, the adjusted OR (95% CI) was 2.6 (1.1–6.1). The adjusted ORs (95% CIs) of GDM comparing the highest-to-lowest quartiles of PD and CAL were 3.8 (1.0–14.0) and 4.5 (1.2–16.9). This study supports the hypothesis of an association between periodontal disease and GDM.
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