The WU-Minn Human Connectome Project: an overview.

The WU-Minn Human Connectome Project: an overview.
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DOI:
10.1016/j.neuroimage.2013.05.041
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发表时间:
2013-10-15
期刊:
影响因子:
5.7
通讯作者:
Ugurbil, Kamil
Ugurbil, Kamil
中科院分区:
医学1区
文献类型:
--
作者:
Van Essen, David C.;Smith, Stephen M.;Barch, Deanna M.;Behrens, Timothy E. J.;Yacoub, Essa;Ugurbil, Kamil

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由华盛顿大学、明尼苏达大学和牛津大学领导的人类连接组计划联盟正在进行一项系统性的工作,以绘制大量健康成年人的宏观人脑回路及其与行为的关系。这篇综述文章的重点是在5年项目的上半年在完善数据采集和分析方法方面取得的进展。初步分析的基础上,最终确定的一套收购和预处理协议证明了非常高的质量的数据,从每一种方式。通过ConnectomeDB数据库发布的第一个季度成像和行为数据表明了HCP数据集免费访问的承诺。总而言之,迄今为止的进展提供了乐观的理由,HCP数据集和相关方法和软件将成为表征人类大脑连接和功能,其与行为的关系以及其遗传性和遗传基础的越来越有价值的资源。
The Human Connectome Project consortium led by Washington University, University of Minnesota, and Oxford University is undertaking a systematic effort to map macroscopic human brain circuits and their relationship to behavior in a large population of healthy adults. This overview article focuses on progress made during the first half of the 5-year project in refining the methods for data acquisition and analysis. Preliminary analyses based on a finalized set of acquisition and preprocessing protocols demonstrate the exceptionally high quality of the data from each modality. The first quarterly release of imaging and behavioral data via the ConnectomeDB database demonstrates the commitment to making HCP datasets freely accessible. Altogether, the progress to date provides grounds for optimism that the HCP datasets and associated methods and software will become increasingly valuable resources for characterizing human brain connectivity and function, their relationship to behavior, and their heritability and genetic underpinnings.
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