Long-chain omega-3 polyunsaturated fatty acids may be beneficial for reducing obesity-a review.
Long-chain omega-3 polyunsaturated fatty acids may be beneficial for reducing obesity-a review.
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作者：
Buckley JD;Howe PRC
目前对抗肥胖症的建议提倡健康饮食和定期体育活动，但许多人难以遵守这些建议。在啮齿动物和人类身上的研究表明，长链omega-3多不饱和脂肪酸(LC n-3 PUFA)可能会引起一系列可能有助于减肥的作用，包括抑制食欲，改善血液循环，促进营养物质输送到骨骼肌，以及基因表达的变化，使新陈代谢转向增加瘦肉组织的积累，增加脂肪氧化和能量消耗，减少脂肪沉积。虽然补充Lcn-3多不饱和脂肪酸已被证明可以减少啮齿动物的肥胖，但在人类中的证据有限。Lcn-3多不饱和脂肪酸摄入量与肥胖之间的流行病学联系尚不确定，但小型横断面研究表明，Lcn-3多不饱和脂肪酸状态的标志物与肥胖标志物之间存在负相关关系。人类干预试验表明，补充LC n-3多不饱和脂肪酸有潜在的好处，特别是当与能量限制的饮食或运动相结合时，但需要更多的良好控制和长期试验来证实这些影响和确定作用机制。
Current recommendations for counteracting obesity advocate the consumption of a healthy diet and participation in regular physical activity, but many individuals have difficulty complying with these recommendations. Studies in rodents and humans have indicated that long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) potentially elicit a number of effects which might be useful for reducing obesity, including suppression of appetite, improvements in circulation which might facilitate nutrient delivery to skeletal muscle and changes in gene expression which shift metabolism toward increased accretion of lean tissue, enhanced fat oxidation and energy expenditure and reduced fat deposition. While LC n-3 PUFA supplementation has been shown to reduce obesity in rodents, evidence in humans is limited. Epidemiological associations between LC n-3 PUFA intakes and obesity are inconclusive but small cross-sectional studies have demonstrated inverse relationships between markers of LC n-3 PUFA status and markers of obesity. Human intervention trials indicate potential benefits of LC n-3 PUFA supplementation, especially when combined with energy-restricted diets or exercise, but more well-controlled and long-term trials are needed to confirm these effects and identify mechanisms of action.
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影响因子：
3.3
作者：
ELAYAN, IM;WINDER, WW
通讯作者：
WINDER, WW
DOI：
10.1111/j.1365-2362.2005.01540.x
发表时间：
2005-08-01
影响因子：
5.5
作者：
Fontani, G;Corradeschi, F;Berra, B
通讯作者：
Berra, B
影响因子：
5.8
作者：
Huang, XF;Xin, X;Storlien, L
通讯作者：
Storlien, L
影响因子：
120.7
作者：
He, K;Rimm, EB;Ascherio, A
通讯作者：
Ascherio, A
影响因子：
3.6
作者：
CUNNANE, SC;MCADOO, KR;HORROBIN, DF
通讯作者：
HORROBIN, DF