Cancer 'survivor-care': II. Disruption of prefrontal brain activation top-down control of working memory capacity as possible mechanism for chemo-fog/brain (chemotherapy-associated cognitive impairment).
Cancer 'survivor-care': II. Disruption of prefrontal brain activation top-down control of working memory capacity as possible mechanism for chemo-fog/brain (chemotherapy-associated cognitive impairment).
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DOI：
10.1111/jcpt.12071
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发表时间：
2013-08
影响因子：
2
通讯作者：
Raffa RB
中科院分区：
文献类型：
--
作者：
Raffa RB
癌症化疗相关的认知障碍（称为“化学雾”或“化学脑”），特别是在记忆方面，已在先前接受化疗的癌症幸存者中自我报告或确定。虽然已经发现了各种各样的缺陷，但一致的主题对视觉空间工作记忆是一种损害。顶叶皮层是储存记忆的主要部位，与化疗引起的损伤有关。然而，如果将两篇最近发表的研究结果结合起来，额叶皮层（前）可能是一个同样可行的目标。最近的两项研究，其中一项假设了工作记忆容量的“自上而下控制”机制，另一项则设想了化疗引起的工作记忆处理过程中大脑激活的改变。一个计算模型和前额叶皮层通过自上而下控制顶叶工作记忆能力在工作记忆中发挥作用的提议与最近的化疗后前额叶过度激活减少的证明是一致的。化疗相关的视觉空间工作记忆损伤可能包括（前）额叶皮层和顶叶皮层。这为基础科学和临床研究提供了新的机遇。
Cancer chemotherapy-associated cognitive impairments (termed ‘chemo-fog’ or ‘chemo-brain’), particularly in memory, have been self-reported or identified in cancer survivors previously treated with chemotherapy. While a variety of deficits have been detected, a consistent theme is a detriment in visuospatial working memory. The parietal cortex, a major site of storage of such memory, is implicated in chemotherapy-induced damage. However, if the findings of two recent publications are combined, the (pre)frontal cortex might be an equally viable target. Two recent studies, one postulating a mechanism for ‘top-down control’ of working memory capacity and another visualizing chemotherapy-induced alterations in brain activation during working memory processing, are reviewed and integrated. A computational model and the proposal that the prefrontal cortex plays a role in working memory via top-down control of parietal working memory capacity is consistent with a recent demonstration of decreased frontal hyperactivation following chemotherapy. Chemotherapy-associated impairment of visuospatial working memory might include the (pre)frontal cortex In addition to the parietal cortex. This provides new opportunity for basic science and clinical investigation.
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