Frontiers of Hydroxyapatite Composites in Bionic Bone Tissue Engineering.
Frontiers of Hydroxyapatite Composites in Bionic Bone Tissue Engineering.
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DOI：
10.3390/ma15238475
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发表时间：
2022-11-28
期刊：
影响因子：
--
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Shi J;Dai W;Gupta A;Zhang B;Wu Z;Zhang Y;Pan L;Wang L
多种因素引起的骨缺损可能导致形态和功能紊乱，严重影响患者的生活质量。自体骨移植是病态的，涉及许多并发症，并且在供体部位提供的体积有限。因此，组织工程骨是修复骨缺损和促进患者功能恢复的更好选择。以羟基磷灰石（HA）复合材料为代表的组织工程骨支架材料除了具有良好的生物相容性外，还具有较强的引导骨再生的能力。制造技术的发展和材料科学的进步，使得HA复合支架与天然骨的成分和力学性能的关系更加密切。支架材料的表面形貌和孔径对于细胞增殖、分化和营养物质交换更为重要。复合支架的降解速率应与成骨速率相匹配，细胞/细胞因子的负载有利于促进新骨的形成。综上所述，毫无疑问，HA复合材料在成分、机械性能和降解方面取得了突破。基于血管化和神经支配的仿生组织工程骨显示出广阔的前景。
Bone defects caused by various factors may cause morphological and functional disorders that can seriously affect patient’s quality of life. Autologous bone grafting is morbid, involves numerous complications, and provides limited volume at donor site. Hence, tissue-engineered bone is a better alternative for repair of bone defects and for promoting a patient’s functional recovery. Besides good biocompatibility, scaffolding materials represented by hydroxyapatite (HA) composites in tissue-engineered bone also have strong ability to guide bone regeneration. The development of manufacturing technology and advances in material science have made HA composite scaffolding more closely related to the composition and mechanical properties of natural bone. The surface morphology and pore diameter of the scaffold material are more important for cell proliferation, differentiation, and nutrient exchange. The degradation rate of the composite scaffold should match the rate of osteogenesis, and the loading of cells/cytokine is beneficial to promote the formation of new bone. In conclusion, there is no doubt that a breakthrough has been made in composition, mechanical properties, and degradation of HA composites. Biomimetic tissue-engineered bone based on vascularization and innervation show a promising future.
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