Intestinal tissue engineering: current concepts and future vision of regenerative medicine in the gut.
Intestinal tissue engineering: current concepts and future vision of regenerative medicine in the gut.
复制标题
肠道组织工程：肠道再生医学的当前概念和未来愿景。
DOI：
10.1111/j.1365-2982.2011.01843.x
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发表时间：
2012-01
影响因子：
3.5
通讯作者：
Raghavan S
中科院分区：
文献类型：
--
作者：
Bitar KN;Raghavan S
胃肠道的功能性组织工程是一个复杂的过程，旨在帮助平滑肌结构层、内在肠神经丛、特化粘膜和上皮细胞以及间质细胞的再生。最终的组织工程结构预期在解剖学和生理学上模拟天然胃肠道。在考虑临床转化时，组织工程构建物的生理功能是最重要的。该构建体包括细胞组分以及生物材料支架组分。总之，这些决定了组织工程构建体在植入时将从宿主引起的免疫应答。在过去十年中，在减轻宿主不良反应方面取得了重大进展。这些包括寻求识别自体细胞来源，如胚胎和成体干细胞，骨髓衍生细胞，神经嵴衍生细胞和肌肉衍生干细胞。生物支架材料的生物相容性和生物降解性不断提高。制造工艺已经发展到允许支架的精确空间结构，以便紧密地模拟体内环境并实现新血管形成。本文将重点介绍从食管到肛门内括约肌的各种神经肌肉结构的功能性组织工程的当前概念和未来愿景。
Functional tissue engineering of the gastrointestinal (GI) tract is a complex process aiming to aid the regeneration of structural layers of smooth muscle, intrinsic enteric neuronal plexuses, specialized mucosa and epithelial cells as well as interstitial cells. The final tissue engineered construct is intended to mimic the native GI tract anatomically and physiologically. Physiological functionality of tissue engineered constructs is of utmost importance while considering clinical translation. The construct comprises of cellular components as well as biomaterial scaffolding components. Together, these determine the immune-response a tissue engineered construct would elicit from a host upon implantation. Over the last decade, significant advances have been made to mitigate adverse host reactions. These include a quest for identifying autologous cell sources like embryonic and adult stem cells, bone marrow-derived cells, neural crest-derived cells and muscle-derived stem cells. Scaffolding biomaterials have been fabricated with increasing biocompatibility and biodegradability. Manufacturing processes have advanced to allow for precise spatial architecture of scaffolds in order to mimic in vivo milieu closely and achieve neovascularization. This review will focus on the current concepts and the future vision of functional tissue engineering of the diverse neuromuscular structures of the GI tract from the esophagus to the internal anal sphincter.
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影响因子：
24.5
作者：
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通讯作者：
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Simmons-Byrd, A