The effect of resting condition on resting-state fMRI reliability and consistency: a comparison between resting with eyes open, closed, and fixated.
The effect of resting condition on resting-state fMRI reliability and consistency: a comparison between resting with eyes open, closed, and fixated.
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DOI：
10.1016/j.neuroimage.2013.04.013
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发表时间：
2013-09
期刊：
影响因子：
5.7
通讯作者：
Birn, Rasmus M.
中科院分区：
文献类型：
--
作者：
Patriat, Remi;Molloy, Erin K.;Meier, Timothy B.;Kirk, Gregory R.;Nair, Veena A.;Meyerand, Mary E.;Prabhakaran, Vivek;Birn, Rasmus M.
静息状态功能磁共振成像（rs-fMRI）已被证明具有中度到高度的可靠性，并在各种各样的主题，网站和扫描仪上产生一致的连接模式。然而，目前还没有一种公认的方法来获取rs-fMRI数据。一些研究中心指导他们的受试者或患者闭着眼睛躺着，而其他研究中心则指导他们的受试者在扫描过程中睁大眼睛，甚至盯着十字架。几项研究根据连接强度比较了这三种静息条件。在我们的研究中，我们评估重测信度（使用组内相关系数）的指标的差异，并在一个主题和主题的特定连接从一个会话到另一个（使用肯德尔的W测试）的排名顺序的连接的一致性。25名健康受试者在三个不同的时间点对每种静息状态进行扫描，同一天扫描两次，两到三个月后再扫描一次。静息状态功能连接的措施进行了评估，在运动，视觉，听觉，注意力和默认模式的网络，并在不同的静息条件下进行比较。在检查的网络中，只有听觉网络在闭眼条件下的连接性显著高于其他两种条件。在默认模式、注意力、视觉和运动网络中，没有发现连接强度的显著条件间差异。总体而言，不同休息条件之间的可靠性和一致性差异相对较小，但结果显着。在所有的网络内连接，以及在默认模式，注意力和听觉网络的统计学显着更大的可靠性时，被试者躺在他们的眼睛固定在一个十字架。相比之下，当受试者睁着眼睛（而不是盯着十字架）时，初级视觉网络连接最可靠。
Resting-state fMRI (rs-fMRI) has been demonstrated to have moderate to high reliability and produces consistent patterns of connectivity across a wide variety of subjects, sites, and scanners. However, there is no one agreed upon method to acquire rs-fMRI data. Some sites instruct their subjects, or patients, to lie still with their eyes closed, while other sites instruct their subjects to keep their eyes open or even fixating on a cross during scanning. Several studies have compared those three resting conditions based on connectivity strength. In our study, we assess differences in metrics of test–retest reliability (using an intraclass correlation coefficient), and consistency of the rank-order of connections within a subject and the ranks of subjects for a particular connection from one session to another (using Kendall's W tests). Twenty-five healthy subjects were scanned at three different time points for each resting condition, twice the same day and another time two to three months later. Resting-state functional connectivity measures were evaluated in motor, visual, auditory, attention, and default-mode networks, and compared between the different resting conditions. Of the networks examined, only the auditory network resulted in significantly higher connectivity in the eyes closed condition compared to the other two conditions. No significant between-condition differences in connectivity strength were found in default mode, attention, visual, and motor networks. Overall, the differences in reliability and consistency between different resting conditions were relatively small in effect size but results were found to be significant. Across all within-network connections, and within default-mode, attention, and auditory networks statistically significant greater reliability was found when the subjects were lying with their eyes fixated on a cross. In contrast, primary visual network connectivity was most reliable when subjects had their eyes open (and not fixating on a cross).
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1121049109
发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
5.7
作者：
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通讯作者：
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影响因子：
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