Transit delay and flow quantification in muscle with continuous arterial spin labeling perfusion-MRI.
Transit delay and flow quantification in muscle with continuous arterial spin labeling perfusion-MRI.
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DOI：
10.1002/jmri.21322
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发表时间：
2008-08
影响因子：
4.4
通讯作者：
Floyd, Thomas F.
中科院分区：
文献类型：
--
作者：
Wu, Wen-Chau;Wang, Jiongjiong;Detre, John A.;Ratcliffe, Sarah J.;Floyd, Thomas F.
关键词：
为了检验使用连续动脉自旋标记（CASL）磁共振成像（MRI）在肌肉中测量流量取决于通过延迟的假设，并检查CASL测量的可重复性。共有23名健康受试者接受了小腿、足部和前臂的CASL成像，具有不同的标记后延迟（PLD = 1000、1500和1900 msec）。实验在3.0T系统上进行。采用骨科止血带系统造成5分钟的局部缺血，随后出现短暂充血。成像在袖带充气前2分钟开始，在袖带释放后3分钟结束。发现CASL能够很好地解析充血流模式的时间过程，有效TR为16秒，尽管我们无法确定即使在长达1900毫秒的PLD下，流量测量也达到了平台。峰值充血流量测量结果与在类似缺血时间后使用对比增强（CE）MRI获得的结果相比，具有优势。基于感兴趣区域（ROI）的重复测量在一小时内变化约20%。在所有的解剖区域研究，流量测量发现增加PLD，这表明在肌肉中的延长的传输延迟。
To test the hypothesis that flow measurements using continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI) in muscle depend upon transit delay, and examine the repeatability of CASL measurements. A total of 23 healthy subjects underwent CASL imaging of the calf, foot, and forearm with varying postlabeling delay (PLD = 1000, 1500, and 1900 msec). Experiments were conducted on a 3.0T system. An orthopedic tourniquet system was employed to create a five-minute period of ischemia followed by a transient hyperemic flow. Imaging commenced two minutes prior to cuff inflation and ended three minutes after cuff release. CASL was found able to well resolve the time course of the hyperemic flow pattern with an effective TR of 16 seconds, although we were unable to establish that a plateau had been reached in the flow measurements even at a PLD as long as 1900 msec. Peak hyperemic flow measurements compared favorably with those obtained with contrast-enhanced (CE) MRI following a similar period of ischemia. Region-of-interest (ROI)–based repeated measurements varied by approximately 20% over a period of one hour. In all anatomic regions studied, flow measurements were found to increase with PLD, suggesting the prolonged transit delay in muscle.
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影响因子：
6
作者：
ELIA, M;KURPAD, A
通讯作者：
KURPAD, A
DOI：
10.1016/0735-1097(93)90549-g
发表时间：
1993-11-01
影响因子：
24
作者：
JONDEAU, G;KATZ, SD;LEJEMTEL, TH
通讯作者：
LEJEMTEL, TH
影响因子：
6.4
作者：
Nygren, AT;Greitz, D;Kaijser, L
通讯作者：
Kaijser, L
影响因子：
3.3
作者：
DETRE, JA;LEIGH, JS;KORETSKY, AP
通讯作者：
KORETSKY, AP
DOI：
10.1097/00004647-199611000-00019
发表时间：
1996-11-01
影响因子：
6.3
作者：
Alsop, DC;Detre, JA
通讯作者：
Detre, JA