Development of high efficiency ventilation bag actuated dry powder inhalers.
Development of high efficiency ventilation bag actuated dry powder inhalers.
复制标题
DOI：
10.1016/j.ijpharm.2014.01.043
复制
发表时间：
2014-04-25
影响因子：
5.8
通讯作者：
Hindle, Michael
中科院分区：
文献类型：
--
作者：
Behara, Srinivas R. B.;Longest, P. Worth;Farkas, Dale R.;Hindle, Michael
关键词：
开发并测试了新型活性干粉吸入器系统，以有效雾化无载体制剂。为了评估吸入器的性能，选择了高流量鼻插管 (HFNC) 治疗期间气雾剂肺部输送的具有挑战性的案例研究。主动输送系统包括用于启动设备的通气袋、包含流量控制孔口和 3D 杆阵列的 DPI，以及具有气雾剂和 HFNC 治疗气体独立入口的流线型鼻插管。进行体外实验以评估装置中的沉积、鼻插管的发射剂量 (ED) 以及粉末解聚。性能最佳的系统实现了 70-80% 的 ED，<5 μm 的细颗粒部分为 65-85%，质量中值空气动力学直径为 1.5 μm，这是受控凝结生长气溶胶输送的目标条件。将流量控制孔口的尺寸从 3.6 减小到 2.3 mm，通过手动滤袋驱动将通过系统的流量从平均 35 LPM 降低到 15 LPM，同时提高 ED 和雾化性能。新设备可用于改善机械通气期间的气雾输送、鼻肺气雾给药，并帮助无法重复使用被动 DPI 的患者。
New active dry powder inhaler systems were developed and tested to efficiently aerosolize a carrier-free formulation. To assess inhaler performance, a challenging case study of aerosol lung delivery during high-flow nasal cannula (HFNC) therapy was selected. The active delivery system consisted of a ventilation bag for actuating the device, the DPI containing a flow control orifice and 3D rod array, and streamlined nasal cannula with separate inlets for the aerosol and HFNC therapy gas. In vitro experiments were conducted to assess deposition in the device, emitted dose (ED) from the nasal cannula, and powder deaggregation. The best performing systems achieved EDs of 70–80% with fine particle fractions <5 μm of 65–85% and mass median aerodynamic diameters of 1.5 μm, which were target conditions for controlled condensational growth aerosol delivery. Decreasing the size of the flow control orifice from 3.6 to 2.3 mm reduced the flow rate through the system with manual bag actuations from an average of 35 to 15 LPM, while improving ED and aerosolization performance. The new devices can be applied to improve aerosol delivery during mechanical ventilation, nose-to-lung aerosol administration, and to assist patients that cannot reproducibly use passive DPIs.
登录
查看更多内容
影响因子：
5.2
作者：
Laube, Beth L.;Sharpless, Gail;Powell, Kenneth
通讯作者：
Powell, Kenneth
影响因子：
10
作者：
Everard, ML;Devadason, SG;LeSouef, PN
通讯作者：
LeSouef, PN
DOI：
10.1111/j.2042-7158.2012.01476.x
发表时间：
2012-09
期刊：
The Journal of pharmacy and pharmacology
影响因子：
--
作者：
Hindle M;Longest PW
通讯作者：
Longest PW
影响因子：
3.8
作者：
Longest, P. Worth;Golshahi, Laleh;Hindle, Michael
通讯作者：
Hindle, Michael
影响因子：
5.8
作者：
Grainger, CI;Alcock, R;Hardy, JG
通讯作者：
Hardy, JG