Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies.
Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies.
复制标题
恶性疟原虫从配子体到卵囊的发育：从功能研究的见解。
DOI：
10.3390/microorganisms11081966
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发表时间：
2023-07-31
期刊：
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
如果不实施阻断传播战略，消灭疟疾就永远不会成功。疟原虫的传播。寄生虫从人类宿主到蚊子载体的传播依赖于脊椎动物宿主外周血中循环的配子母细胞。一旦在吸血期间被蚊子摄入，这些有性形式经历了一系列激进的形态和代谢变化，以生存并从肠道发展到唾液腺，在那里它们将等待被注射到脊椎动物宿主中。有效的传播阻断策略的设计需要彻底了解驱动配子母细胞，配子，有性生殖和随后的蚊子内分化的所有机制。恶性疟原虫在其整个生命周期中形态和功能的急剧变化依赖于阶段特异性基因表达的严格调控。本文综述了恶性疟原虫在人和蚊媒中的性阶段发育以及受精卵向卵囊分化的机制。功能研究揭示了恶性疟原虫在其复杂的生命周期中成功表达阶段特异性功能产物的机制，从而为我们开发新的治疗方法提供了潜在的靶点。这些机制是基于对各种疟原虫物种进行的研究，主要包括恶性疟原虫和啮齿类疟原虫伯氏疟原虫。然而，表观遗传学、基因组学、转录组学、蛋白质组学和功能遗传学研究在提高对疟疾作为一种疾病的理解方面的巨大潜力仍然部分未被利用，这是因为使用人类疟疾寄生虫和田间分离株的研究存在局限性。
Malaria elimination may never succeed without the implementation of transmission-blocking strategies. The transmission of Plasmodium spp. parasites from the human host to the mosquito vector depends on circulating gametocytes in the peripheral blood of the vertebrate host. Once ingested by the mosquito during blood meals, these sexual forms undergo a series of radical morphological and metabolic changes to survive and progress from the gut to the salivary glands, where they will be waiting to be injected into the vertebrate host. The design of effective transmission-blocking strategies requires a thorough understanding of all the mechanisms that drive the development of gametocytes, gametes, sexual reproduction, and subsequent differentiation within the mosquito. The drastic changes in Plasmodium falciparum shape and function throughout its life cycle rely on the tight regulation of stage-specific gene expression. This review outlines the mechanisms involved in Plasmodium falciparum sexual stage development in both the human and mosquito vector, and zygote to oocyst differentiation. Functional studies unravel mechanisms employed by P. falciparum to orchestrate the expression of stage-specific functional products required to succeed in its complex life cycle, thus providing us with potential targets for developing new therapeutics. These mechanisms are based on studies conducted with various Plasmodium species, including predominantly P. falciparum and the rodent malaria parasites P. berghei. However, the great potential of epigenetics, genomics, transcriptomics, proteomics, and functional genetic studies to improve the understanding of malaria as a disease remains partly untapped because of limitations in studies using human malaria parasites and field isolates.
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影响因子：
3.7
作者：
Behnke MS;Wootton JC;Lehmann MM;Radke JB;Lucas O;Nawas J;Sibley LD;White MW
通讯作者：
White MW
表型筛选鉴定与人类疟原虫恶性疟原虫配子体发育相关的遗传因素。
影响因子：
3.7
作者：
通讯作者：
--
影响因子：
9.8
作者：
Bozdech, Zbynek;Llinas, Manuel;Pulliam, Brian Lee;Wong, Edith D;Zhu, Jingchun;DeRisi, Joseph L
通讯作者：
DeRisi, Joseph L
影响因子：
9.6
作者：
Baton, LA;Ranford-Cartwright, LC
通讯作者：
Ranford-Cartwright, LC
影响因子：
7.3
作者：
Batugedara G;Le Roch KG
通讯作者：
Le Roch KG