Effects of Ibuprofen and Resistance Training on Bone and Muscle: A Randomized Controlled Trial in Older Women
Effects of Ibuprofen and Resistance Training on Bone and Muscle: A Randomized Controlled Trial in Older Women
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布洛芬和阻力训练对骨骼和肌肉的影响：老年女性的随机对照试验
DOI：
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发表时间：
2016
影响因子：
4.1
通讯作者：
S. Kontulainen
中科院分区：
文献类型：
--
作者：
W. Duff;P. Chilibeck;D. Candow;Julianne J Gordon;Riley S. Mason;R. Taylor;M. Szafron;A. Baxter;G. Zello;S. Kontulainen
介绍/目的抗阻训练与布洛芬补充剂可以改善绝经后妇女的肌肉骨骼健康。本研究的目的是确定抗阻训练和布洛芬补充剂对绝经后妇女骨骼和肌肉特性的疗效。方法参与者（n = 90，65.3 ± 4.9岁）被随机分配到：监督阻力训练或拉伸（安慰剂运动）与运动后布洛芬（400 mg）或安慰剂补充3 d·wk-1（9个月）。基线和干预后测量包括使用外周定量计算机断层扫描对前臂和小腿进行远端和骨干扫描。远端部位结果包括总骨和松质骨的横截面积、含量和密度，以及估计的压缩骨强度。轴部位结局包括总骨面积;皮质骨面积、含量和密度;扭转时估计的骨强度;以及肌肉面积和密度。结果桡骨远端总骨含量（P = 0.009）和桡骨干骨皮质密度（P = 0.038）的骨密度-补充-时间交互作用显著。与阻力训练（0.6%; P = 0.032）和单独使用布洛芬（0.5%; P = 0.050）相比，使用布洛芬的阻力训练降低了桡骨远端的总骨含量（-1.5%）。在安慰剂和布洛芬补充组之间，桡骨干皮质密度的变化存在差异（-1.8% vs 1.1%; P = 0.050）。阻力训练比拉伸训练更能保持小腿的肌肉密度（-3.1% vs-5.4%; P = 0.015）。结论抗阻训练后立即服用布洛芬对桡骨远端的骨矿物质含量有有害影响，而抗阻训练或布洛芬补充剂单独预防骨丢失。阻力训练可以防止小腿肌肉密度下降。
Introduction/Purpose Resistance training with ibuprofen supplementation may improve musculoskeletal health in postmenopausal women. The study purpose was to determine the efficacy of resistance training and ibuprofen supplementation on bone and muscle properties in postmenopausal women. Methods Participants (n = 90, 65.3 ± 4.9 yr) were randomly assigned to: supervised resistance training or stretching (placebo-exercise) with postexercise ibuprofen (400 mg) or placebo supplementation for 3 d·wk−1 (9 months). Baseline and postintervention measurements included distal and shaft scans of the forearm and lower leg using peripheral quantitative computed tomography. Distal site outcomes included cross-sectional area, content, and density for total and trabecular bone, as well as estimated bone strength in compression. Shaft site outcomes included total bone area; cortical bone area, content, and density; estimated bone strength in torsion; and muscle area and density. Results Exercise–supplement–time interactions for total bone content at the distal radius (P = 0.009) and cortical density at the radius shaft (P = 0.038) were significant. Resistance training with ibuprofen decreased total bone content (−1.5%) at the distal radius in comparison to the resistance training (0.6%; P = 0.032) and ibuprofen alone (0.5%; P = 0.050). Change in cortical density at the radius shaft differed between the stretching with placebo and ibuprofen supplementation groups (−1.8% vs 1.1%; P = 0.050). Resistance training preserved muscle density in the lower leg more so than stretching (−3.1% vs −5.4%; P = 0.015). Conclusions Ibuprofen consumed immediately after resistance training had a deleterious effect on bone mineral content at the distal radius, whereas resistance training or ibuprofen supplementation individually prevented bone loss. Resistance training prevented muscle density decline in the lower leg.
DOI：
10.1093/gerona/gls068
发表时间：
2012-11-01
影响因子：
5.1
作者：
Horstman, Astrid M.;Dillon, E. Lichar;Sheffield-Moore, Melinda
通讯作者：
Sheffield-Moore, Melinda
高强度抗阻运动后肌肉蛋白质合成升高的时间过程。
DOI：
10.1139/h95-038
发表时间：
1995
期刊：
Canadian journal of applied physiology = Revue canadienne de physiologie appliquee
影响因子：
--
作者：
MacDougall,JD;Gibala,MJ;Tarnopolsky,MA;MacDonald,JR;Interisano,SA;Yarasheski,KE
通讯作者：
Yarasheski,KE
DOI：
10.1016/j.jamda.2011.01.003
发表时间：
2011-05
影响因子：
7.6
作者：
Fielding, Roger A.;Vellas, Bruno;Evans, William J.;Bhasin, Shalender;Morley, John E.;Newman, Anne B.;van Kan, Gabor Abelian;Andrieu, Sandrine;Bauer, Juergen;Breuille, Denis;Cederholm, Tommy;Chandler, Julie;De Meynard, Capucine;Donini, Lorenzo;Harris, Tamara;Kannt, Aimo;Guibert, Florence Keime;Onder, Graziano;Papanicolaou, Dimitris;Rolland, Yves;Rooks, Daniel;Sieber, Cornet;Souhami, Elisabeth;Verlaan, Sjors;Zamboni, Mauro
通讯作者：
Zamboni, Mauro