Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
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DOI：
10.1016/j.jamda.2011.01.003
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发表时间：
2011-05
影响因子：
7.6
通讯作者：
Zamboni, Mauro
中科院分区：
文献类型：
--
作者：
Fielding, Roger A.;Vellas, Bruno;Evans, William J.;Bhasin, Shalender;Morley, John E.;Newman, Anne B.;van Kan, Gabor Abelian;Andrieu, Sandrine;Bauer, Juergen;Breuille, Denis;Cederholm, Tommy;Chandler, Julie;De Meynard, Capucine;Donini, Lorenzo;Harris, Tamara;Kannt, Aimo;Guibert, Florence Keime;Onder, Graziano;Papanicolaou, Dimitris;Rolland, Yves;Rooks, Daniel;Sieber, Cornet;Souhami, Elisabeth;Verlaan, Sjors;Zamboni, Mauro
肌肉减少症是与年龄相关的骨骼肌质量和功能丧失，对虚弱、残疾和医疗保健计划的发展具有相当大的社会后果。2009年11月18日，一群来自学术界和工业界的老年病学家和科学家在罗马，意大利会面，达成了肌肉减少症的共识定义。目前的共识定义是由与会者一致通过，如下：肌肉减少症定义为与年龄相关的骨骼肌质量和功能的损失。肌肉减少症的原因是多因素的，可以包括废用、内分泌功能改变、慢性疾病、炎症、胰岛素抵抗和营养缺乏。虽然恶病质可能是肌肉减少症的一个组成部分，但这两种情况并不相同。肌肉减少症的诊断应考虑在所有老年患者谁目前与观察到的身体功能，力量，或整体健康下降。对于卧床不起、不能独立从椅子上起身或测量的步态速度小于1.0 m·s−1的患者，应特别考虑肌肉减少症。符合这些标准的患者应使用双能X线吸收测定法（DXA）进一步进行身体成分评估，并使用当前验证的定义定义肌肉减少症。肌肉减少症的诊断与步态速度小于1 m·s−1和客观测量的低肌肉质量一致（例如：相对于ht 2的肌肉质量≤ 7.23 kg/ m2（男性）≤ 5.67 kg/m2（男性））。肌肉减少症在老年人中是一种非常普遍的疾病，可导致残疾、住院和死亡。
Sarcopenia, the age associated loss of skeletal muscle mass and function, has considerable societal consequences for the development of frailty, disability and health care planning. A group of geriatricians and scientists from academia and industry met in Rome, Italy on November 18, 2009 to arrive at a consensus definition of sarcopenia. The current consensus definition was approved unanimously by the meeting participants and is as follows: Sarcopenia is defined as the age-associated loss of skeletal muscle mass and function. The causes of sarcopenia are multi-factorial and can include disuse, altered endocrine function, chronic diseases, inflammation, insulin resistance, and nutritional deficiencies. While cachexia may be a component of sarcopenia, the two conditions are not the same. The diagnosis of sarcopenia should be considered in all older patients who present with observed declines in physical function, strength, or overall health. Sarcopenia should specifically be considered in patients who are bedridden, cannot independently rise from a chair, or who have a measured gait speed less that 1.0 m·s−1. Patients who meet these criteria should further undergo body composition assessment using dual energy x-ray absorptiometry (DXA) with sarcopenia being defined using currently validated definitions. A diagnosis of sarcopenia is consistent with a gait speed of less than 1 m·s−1 and an objectively measured low muscle mass (eg: appendicular mass relative to ht2 that is ≤ 7.23 kg/ m2 in men ≤ 5.67 kg/ m2 in men). Sarcopenia is a highly prevalent condition in older persons that leads to disability, hospitalization and death.
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DOI：
10.1093/gerona/52a.5.m275
发表时间：
1997-09-01
影响因子：
5.1
作者：
Ferrucci, L;Guralnik, JM;Fried, LP
通讯作者：
Fried, LP
影响因子：
--
作者：
COHN, SH;VARTSKY, D;ELLIS, KJ
通讯作者：
ELLIS, KJ
影响因子：
3.3
作者：
Gallagher, D;Visser, M;Heymsfield, SB
通讯作者：
Heymsfield, SB
影响因子：
4.2
作者：
EVANS, WJ;CAMPBELL, WW
通讯作者：
CAMPBELL, WW
DOI：
10.1046/j.1532-5415.2002.50605.x
发表时间：
2002-12-01
影响因子：
6.3
作者：
Ferrucci, L;Penninx, BWJH;Guralnik, JM
通讯作者：
Guralnik, JM