The time course for elevated muscle protein synthesis following heavy resistance exercise.

The time course for elevated muscle protein synthesis following heavy resistance exercise.
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高强度抗阻运动后肌肉蛋白质合成升高的时间过程。

DOI:
10.1139/h95-038
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发表时间:
1995
期刊:
Canadian journal of applied physiology = Revue canadienne de physiologie appliquee
影响因子:
--
通讯作者:
Yarasheski,KE
Yarasheski,KE
中科院分区:
--
文献类型:
--
作者:
MacDougall,JD;Gibala,MJ;Tarnopolsky,MA;MacDonald,JR;Interisano,SA;Yarasheski,KE

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研究表明,人类在进行一次高强度阻力训练后 4 小时内,肌肉蛋白合成率 (MPS) 提高了 50%,在训练后 24 小时内提高了 109%。这项研究通过检查训练后 36 小时的速率,进一步研究了肌肉蛋白质合成升高的时间过程。六名健康的年轻男性用一只手臂进行了 12 组 6 至 12 RM 的肘部弯曲练习,而另一只手臂作为对照。 MPS 是根据 L-[1,2−13C2] 亮氨酸在 11 小时内使用引物恒定输注技术进入双臂肱二头肌的体内掺入率来计算的。平均运动后 36 小时,运动臂的 MPS 已恢复到对照臂值的 14% 以内,差异不显着。结论是,经过一轮大强度阻力训练后,MPS迅速增加,24小时时增加一倍以上,随后迅速下降,36小时时几乎恢复到基线水平。 关键词:L-[−13C]亮氨酸,肌肉肥大,训练频率,质谱
It has been shown that muscle protein synthetic rate (MPS) is elevated in humans by 50% at 4 hrs following a bout of heavy resistance training, and by 109% at 24 hrs following training. This study further examined the time course for elevated muscle protein synthesis by examining its rate at 36 hrs following a training session. Six healthy young men performed 12 sets of 6- to 12-RM elbow flexion exercises with one arm while the opposite arm served as a control. MPS was calculated from the in vivo rate of incorporation of L-[1,2−13C2] leucine into biceps brachii of both arms using the primed constant infusion technique over 11 hrs. At an average time of 36 hrs postexercise, MPS in the exercised arm had returned to within 14% of the control arm value, the difference being nonsignificant. It is concluded that following a bout of heavy resistance training, MPS increases rapidly, is more than double at 24 hrs, and thereafter declines rapidly so that at 36 hrs it has almost returned to baseline.Key words: L-[−13C] leucine, muscle hypertrophy, training frequency, mass spectrometry
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