Cancer cell detection and imaging: MRI-SERS bimodal splat-shaped Fe3O4/Au nanocomposites
Cancer cell detection and imaging: MRI-SERS bimodal splat-shaped Fe3O4/Au nanocomposites
复制标题
癌细胞检测和成像：MRI-SERS 双峰片状 Fe3O4/Au 纳米复合材料
DOI：
10.1016/j.cclet.2018.01.028
复制
发表时间：
2019-01
影响因子：
9.1
通讯作者：
Aiguo Wu
中科院分区：
文献类型：
--
作者：
Xinmei Zhao;Leyong Zeng;Narayan Hosmane;Yan Gong;Aiguo Wu
多功能造影剂的发展对肿瘤的诊断具有重要意义。然而，仍需努力设计和改善用于癌症早期检测的造影剂的生物相容性。在这里，我们合成了片状Fe3O4/Au纳米复合材料，用于多模式生物医学应用。透射电子显微镜结果表明，Fe3O4/Au为片状结构，在130 nm范围内均匀分布在水介质中。将纳米复合材料与MCF-7细胞孵育，研究其磁共振成像(MRI)和表面增强拉曼散射(SERS)活性。获得了良好的T2MRI和增强的SERS特性，且没有任何细胞毒性。这些结果表明，所合成的片状Fe3O4/Au纳米复合材料可能是一种很有前途的MRI/SERS双探针用于肿瘤检测。
The development of multifunctional contrast agents contributes significant character in the diagnosis of cancer. However, still efforts are required to design and improve the biocompatibility of contrast agents for early detection of cancer. Herein, we synthesized splat shape Fe3O4/Au nanocomposites for multimode biomedical applications. Transmission electron microscopy (TEM) results showed that the splat-like Fe3O4/Au structure was in the range of 130 nm and homogeneously distributed in the aqueous medium. The nanocomposites were incubated with MCF-7 cells to investigate the magnetic resonance imaging (MRI) and surface-enhanced Raman scattering (SERS) activities. The excellent T2MRI and enhanced SERS properties were obtained without any cytotoxicity. These results demonstrated that as-synthesized splat-shaped Fe3O4/Au nanocomposites may be a promising MRI/SERS dual probe for the tumor detection.
登录
查看更多内容
影响因子：
14
作者：
Xingjun Zhu;Jing Zhou;Min Chen;Mei Shi;Wei Feng;Fuyou Li
通讯作者：
Xingjun Zhu;Jing Zhou;Min Chen;Mei Shi;Wei Feng;Fuyou Li
影响因子：
16.6
作者：
Xu, Chenjie;Xie, Jin;Sun, Shouheng
通讯作者：
Sun, Shouheng
影响因子：
3.7
作者：
Yueming Zhai;Junfeng Zhai;Yuling Wang;Shaojun Guo;Wen Ren;S. Dong
通讯作者：
Yueming Zhai;Junfeng Zhai;Yuling Wang;Shaojun Guo;Wen Ren;S. Dong
影响因子：
15
作者：
Lee, Nohyun;Cho, Hye Rim;Hyeon, Taeghwan
通讯作者：
Hyeon, Taeghwan
影响因子：
9.1
作者：
Z. Duan;Xinbao Gao;Tianli Li;Yao Kai;Xu-Ming Xie
通讯作者：
Z. Duan;Xinbao Gao;Tianli Li;Yao Kai;Xu-Ming Xie