Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and women.
Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and women.
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DOI：
10.1016/j.neurobiolaging.2008.08.004
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发表时间：
2010-07
影响因子：
4.2
通讯作者：
Launer, Lenore J.
中科院分区：
文献类型：
--
作者：
Rosano, Caterina;Sigurdsson, Sigurdur;Siggeirsdottir, Kristin;Phillips, Caroline L.;Garcia, Melissa;Jonsson, Palmi V.;Eiriksdottir, Gudny;Newman, Anne B.;Harris, Tamara B.;van Buchem, Mark A.;Gudnason, Vilmundur;Launer, Lenore J.
评估微观和宏观脑结构异常的标志物是否与老年男性和女性的步态较慢相关，相互独立，也独立于健康相关疾病以及行为，认知和外周功能。对795名AGES-雷克雅未克研究队列的参与者（平均75.6岁，58.9%为女性）进行了磁化传递率[MTR]、白色高信号[WMH]、脑萎缩[BA]和脑梗死[BI]的测量。在女性中，较低的MTR，较高的WMH和BA，但不是BI，仍然与彼此独立和其他协变量的步态较慢。在男性中，WMH和BA，而不是MTR或BI，仍然与彼此独立的步态较慢相关。只有肌肉力量，执行控制功能和抑郁测试分数大大削弱了这些协会。老年人的MTR可能是与步态较慢相关的脑异常的重要附加标志。研究探讨大脑微观和宏观结构异常与步态之间的关系以及介导因素的作用是必要的。
To assess whether markers of micro- and macro-structural brain abnormalities are associated with slower gait in older men and women independent of each other, and also independent of health-related conditions and of behavioral, cognitive and peripheral function. Magnetization transfer ratio [MTR], white matter hyperintensities [WMH], brain atrophy [BA] and brain infarcts [BI] were measured in 795 participants of the AGES-Reykjavik Study cohort (mean 75.6yrs, 58.9% women). In women, lower MTR, higher WMH and BA, but not BI, remained associated with slower gait independent of each other and of other covariates. In men, WMH and BA, but not MTR or BI, remained associated with slower gait independently of each other. Only muscle strength, executive control function and depression test scores substantially attenuated these associations. MTR in older adults may be an important additional marker of brain abnormalities associated with slower gait. Studies to explore the relationship between brain micro- and macrostructural abnormalities with gait and the role of mediating factors are warranted.
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DOI：
10.1037/0096-1523.11.5.617
发表时间：
1985-01-01
影响因子：
2.1
作者：
KERR, B;CONDON, SM;MCDONALD, LA
通讯作者：
MCDONALD, LA
影响因子：
8.3
作者：
MILLER, RE;SHAPIRO, AP;HOSUTT, JA
通讯作者：
HOSUTT, JA
影响因子：
5.7
作者：
Inzitari, Marco;Newman, Anne B.;Rosano, Caterina
通讯作者：
Rosano, Caterina
影响因子：
11
作者：
Haggard, P;Cockburn, J;Wade, D
通讯作者：
Wade, D
DOI：
10.1111/j.1532-5415.1999.tb02997.x
发表时间：
1999-03-01
影响因子：
6.3
作者：
Camicioli, R;Moore, MM;Kaye, JA
通讯作者：
Kaye, JA