Preliminary evidence of altered gray and white matter microstructural development in the frontal lobe of adolescents with attention-deficit hyperactivity disorder: a diffusional kurtosis imaging study.
Preliminary evidence of altered gray and white matter microstructural development in the frontal lobe of adolescents with attention-deficit hyperactivity disorder: a diffusional kurtosis imaging study.
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DOI：
10.1002/jmri.22397
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发表时间：
2011-01
影响因子：
4.4
通讯作者：
Jensen, Jens H.
中科院分区：
文献类型：
--
作者：
Helpern, Joseph A.;Adisetiyo, Vitria;Falangola, Maria F.;Hu, Caixia;Di Martino, Adriana;Williams, Kathleen;Castellanos, Francisco X.;Jensen, Jens H.
采用扩散峰度成像（DKI）研究非高斯水扩散，以评估注意缺陷多动障碍（ADHD）青少年与正常发育对照（TDC）青少年前额叶皮层（PFC）灰质（GM）和白色质（WM）微结构变化的年龄效应。在这项初步的横断面研究中，在3 T条件下采集了TDC（n = 13）和ADHD青少年（n = 12）的T1加权磁化准备快速梯度回波（MPWE）和DKI图像。对PFC感兴趣区域（ROI）进行回归分析。TDC显示出一个显着的峰度增加的WM微观结构的复杂性，从12至18岁，特别是在径向方向，而WM微观结构在ADHD是停滞在轴向和径向方向。在ADHD中，GM微结构也缺乏与TDC中所见的复杂性的显著年龄相关性增加;只有峰度测量能够检测到这种差异。这些发现支持了ADHD是一种影响额纹状体WM的疾病的流行理论。我们的研究是第一个直接量化的异常年龄相关的轨迹在ADHD GM微结构，这表明使用DKI的非高斯定向扩散的评估提供了更敏感和补充的信息，组织微结构的变化比传统的扩散成像方法。
To investigate non-Gaussian water diffusion using diffusional kurtosis imaging (DKI) to assess age effects on gray matter (GM) and white matter (WM) microstructural changes in the prefrontal cortex (PFC) of adolescents with attention-deficit hyperactivity disorder (ADHD) compared to typically developing controls (TDC). In this preliminary cross-sectional study, T1-weighted magnetization-prepared rapid gradient echo (MPRAGE) and DKI images were acquired at 3T from TDC (n = 13) and adolescents with ADHD (n = 12). Regression analysis of the PFC region of interest (ROI) was conducted. TDC show a significant kurtosis increase of WM microstructural complexity from 12 to 18 years of age, particularly in the radial direction, whereas WM microstructure in ADHD is stagnant in both the axial and radial directions. In ADHD, GM microstructure also lacked a significant age-related increase in complexity as seen in TDC; only kurtosis measures were able to detect this difference. These findings support the prevailing theory that ADHD is a disorder affecting frontostriatal WM. Our study is the first to directly quantify an aberrant age-related trajectory in ADHD within GM microstructure, suggesting that the assessment of non-Gaussian directional diffusion using DKI provides more sensitive and complementary information about tissue microstructural changes than conventional diffusion imaging methods.
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影响因子：
1.7
作者：
Hamilton LS;Levitt JG;O'Neill J;Alger JR;Luders E;Phillips OR;Caplan R;Toga AW;McCracken J;Narr KL
通讯作者：
Narr KL
影响因子：
2.9
作者：
Jensen, Jens H.;Helpern, Joseph A.
通讯作者：
Helpern, Joseph A.
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
3.3
作者：
Ma, XY;Kadah, YM;Hu, XP
通讯作者：
Hu, XP
影响因子：
120.7
作者：
Castellanos, FX;Lee, PP;Rapoport, JL
通讯作者：
Rapoport, JL