External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice.
External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice.
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帕利德斯外部对背纹状体的输入可调节雄性小鼠的习惯性寻求行为。
DOI：
10.1038/s41467-023-39545-8
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发表时间：
2023-07-12
影响因子：
16.6
通讯作者：
Choi DS
中科院分区：
文献类型：
--
作者：
Baker M;Kang S;Hong SI;Song M;Yang MA;Peyton L;Essa H;Lee SW;Choi DS
外部苍白球（GPe）通过整个基底神经节的GABA能投射协调动作选择。GPe arkypallidal（arky）神经元专门投射到背侧纹状体，调节目标导向和习惯性寻求。然而，GPe arky神经元在奖赏寻求中的作用仍然未知。在这里，我们发现大多数arky神经元靶向背外侧纹状体（DLS）。使用纤维光度法，我们发现，arky活动更高的随机间隔（RI;习惯）相比，随机比率（RR;目标）操作性条件反射。支持向量机分析表明，arky神经元活动有足够的信息来区分RR和RI行为。对这个arkyGPe→DLS回路的基因切除促进了从目标导向到习惯行为的转变。相反，趋化激活全球减少寻求行为，这是由系统性D1 R激动。我们的研究结果揭示了这个arkyGPe→DLS回路在抑制雄性小鼠的习惯性寻求中的作用，这与成瘾行为和其他强迫性疾病有关。苍白球的外部参与动作选择。在这里，作者研究了雄性小鼠在目标导向和习惯性寻求行为中，背外侧纹状体的arkypallidal神经元回路的功能。
The external globus pallidus (GPe) coordinates action-selection through GABAergic projections throughout the basal ganglia. GPe arkypallidal (arky) neurons project exclusively to the dorsal striatum, which regulates goal-directed and habitual seeking. However, the role of GPe arky neurons in reward-seeking remains unknown. Here, we identified that a majority of arky neurons target the dorsolateral striatum (DLS). Using fiber photometry, we found that arky activities were higher during random interval (RI; habit) compared to random ratio (RR; goal) operant conditioning. Support vector machine analysis demonstrated that arky neuron activities have sufficient information to distinguish between RR and RI behavior. Genetic ablation of this arkyGPe→DLS circuit facilitated a shift from goal-directed to habitual behavior. Conversely, chemogenetic activation globally reduced seeking behaviors, which was blocked by systemic D1R agonism. Our findings reveal a role of this arkyGPe→DLS circuit in constraining habitual seeking in male mice, which is relevant to addictive behaviors and other compulsive disorders. The external part of the globus pallidus is involved in action-selection. Here, the authors investigate the function of an arkypallidal neuronal circuit to the dorsolateral striatum in goal-directed and habitual-seeking behaviors in male mice.
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DOI：
10.1073/pnas.0610877104
发表时间：
2007-02-13
影响因子：
11.1
作者：
Chelur, Dattananda S.;Chalfie, Martin
通讯作者：
Chalfie, Martin
影响因子：
4.7
作者：
Hong SI;Kang S;Baker M;Choi DS
通讯作者：
Choi DS
影响因子：
10.6
作者：
Cools, Roshan;D'Esposito, Mark
通讯作者：
D'Esposito, Mark
影响因子：
9.2
作者：
Aristieta, Asier;Barresi, Massimo;Mallet, Nicolas P.
通讯作者：
Mallet, Nicolas P.
影响因子：
10.6
作者：
Corbit, Laura H.;Nie, Hong;Janak, Patricia H.
通讯作者：
Janak, Patricia H.