IMAGING STUDY: Exposure to smoking cues during an emotion recognition task can modulate limbic fMRI activation in cigarette smokers
IMAGING STUDY: Exposure to smoking cues during an emotion recognition task can modulate limbic fMRI activation in cigarette smokers
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影像学研究：在情绪识别任务期间暴露于吸烟线索可以调节吸烟者的边缘功能磁共振成像激活
作者：
E. Artiges;E. Ricalens;S. Berthoz;M. Krebs;J. Penttilä;C. Trichard;J. Martinot
吸烟线索（SC）是指与吸烟相关的环境刺激，可能引发吸烟者的渴望和戒断症状，并使其易于复发。虽然以前的脑成像研究已经探索了对SC的神经反应，但没有研究表征了SC对从事与吸烟无关的需要注意力的认知任务的吸烟者大脑活动的影响。13名吸烟者和一组人口统计学匹配的13名健康非吸烟者参加了一项快速事件相关功能磁共振成像（fMRI）研究，该研究涉及在需要高度注意力的情绪识别试验期间整合SC和中性线索（NC）的视觉任务。在吸烟者的行为表现中未检测到显著的SC诱导的改变。fMRI结果显示，非吸烟者在SC和NC试验之间没有表现出差异;相反，吸烟者在边缘系统、边缘系统和纹状体网络中表现出SC诱导的广泛失活，这些网络通常与成瘾有关，而在右背外侧前额叶皮层中表现出激活。此外，在吸烟者中检测到右脑岛失活与吸烟依赖严重程度（Fagerström测试）之间的相关性。这些结果表明，吸烟者对SC的神经反应性可以在认知挑战的背景下进行修改。这可能反映了吸烟者抑制暗示诱导的渴望的能力，并可能有助于戒烟。
Smoking cues (SCs) refer to smoking‐associated environmental stimuli that may trigger craving and withdrawal symptoms, and predispose to relapse in smokers. Although previous brain imaging studies have explored neural responses to SCs, no study has characterized the effects of SCs on cerebral activity in smokers engaged in an attention‐demanding cognitive task that is unrelated to smoking. Thirteen tobacco smokers and a demographically matched group of 13 healthy non‐smokers participated in a fast event‐related functional magnetic resonance imaging (fMRI) study that involved a visual task integrating SCs and neutral cues (NCs) during emotion recognition trials requiring a high level of attention. No significant SC‐induced alterations were detected in smokers' behavioural performance. fMRI results show that non‐smokers exhibited no difference between SC and NC trials; in contrast, smokers showed SC‐induced widespread deactivations in a limbic, paralimbic and striatal network classically involved in addiction, and activation in the right dorsolateral prefrontal cortex. In addition, a correlation between deactivation of the right insula and the severity of smoking dependence (Fagerström test) was detected in smokers. These results suggest that the neural reactivity of smokers to SCs can be modified in the context of a cognitive challenge. This could reflect smokers' ability to inhibit cue‐induced craving and may help in smoking cessation.
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影响因子：
6
作者：
Carter, BL;Tiffany, ST
通讯作者：
Tiffany, ST
影响因子：
4.2
作者：
Ehrman, RN;Robbins, SJ;O'Brien, CP
通讯作者：
O'Brien, CP
影响因子：
4.1
作者：
O'Brien, CP;Childress, AR;Robbins, SJ
通讯作者：
Robbins, SJ
影响因子：
17.7
作者：
Stein, EA;Pankiewicz, J;Bloom, AS
通讯作者：
Bloom, AS
吸烟线索暴露对工作记忆表现的遗留影响。
DOI：
10.1080/14622200701243144
发表时间：
2007
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
--
作者：
Wilson,StephenJ;Sayette,MichaelA;Fiez,JulieA;Brough,Elizabeth
通讯作者：
Brough,Elizabeth